Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4423672..4424298 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GN113_RS19290 Protein ID WP_155323572.1
Coordinates 4423672..4423962 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GN113_RS19295 Protein ID WP_155313818.1
Coordinates 4423972..4424298 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS19265 4419367..4419813 + 447 WP_155323567.1 hypothetical protein -
GN113_RS19270 4420067..4421356 + 1290 WP_155323568.1 IS701 family transposase -
GN113_RS19275 4422282..4422683 - 402 WP_155323569.1 type II toxin-antitoxin system VapC family toxin -
GN113_RS19280 4422683..4422910 - 228 WP_155323570.1 antitoxin -
GN113_RS19285 4423081..4423464 + 384 WP_155323571.1 hypothetical protein -
GN113_RS19290 4423672..4423962 + 291 WP_155323572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN113_RS19295 4423972..4424298 + 327 WP_155313818.1 putative addiction module antidote protein Antitoxin
GN113_RS19300 4424676..4424912 - 237 WP_155323573.1 type II toxin-antitoxin system YafQ family toxin -
GN113_RS19305 4424909..4425169 - 261 WP_155323574.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GN113_RS19310 4425345..4426655 - 1311 WP_155321603.1 ISL3 family transposase -
GN113_RS19315 4427269..4427907 + 639 WP_155323575.1 peptidoglycan-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10870.74 Da        Isoelectric Point: 10.7928

>T33431 WP_155323572.1 NZ_AP021876:4423672-4423962 [Desulfosarcina ovata subsp. sediminis]
MIEIRKTETFAKWLDGLNDIRARARILVRIERLAAGNPGDVKPVGEGVSELRIDYGPGYRVYYKKRGSKLIILLAGGDKR
TQSKDIKFVLRLAQNL

Download         Length: 291 bp

>T33431 NZ_AP021876:4423672-4423962 [Desulfosarcina ovata subsp. sediminis]
ATGATCGAAATCCGTAAGACTGAGACTTTTGCCAAGTGGCTTGACGGTTTGAACGATATCCGTGCACGTGCTCGTATTTT
GGTAAGGATCGAACGGTTGGCAGCAGGTAATCCTGGTGATGTTAAACCTGTCGGCGAAGGAGTTTCAGAGTTACGTATCG
ACTACGGCCCAGGTTACCGCGTTTATTACAAAAAGCGAGGCAGCAAATTGATCATTCTATTGGCTGGTGGCGATAAGCGC
ACTCAATCCAAGGACATAAAATTCGTATTGCGCCTTGCTCAGAATCTATAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11662.34 Da        Isoelectric Point: 6.7186

>AT33431 WP_155313818.1 NZ_AP021876:4423972-4424298 [Desulfosarcina ovata subsp. sediminis]
MSKIITTRYDVAEHLRTPEEMAAYLEACFEEASGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERRPTFDT
ILKVIGALGLKLHAEAIHTNINTGQPVT

Download         Length: 327 bp

>AT33431 NZ_AP021876:4423972-4424298 [Desulfosarcina ovata subsp. sediminis]
ATGTCTAAAATCATCACAACACGCTACGATGTCGCTGAGCATCTTCGGACGCCGGAGGAAATGGCAGCCTATCTTGAAGC
TTGTTTCGAGGAGGCATCAGGTGATGCTGCTTTCATTGCCAAAGCCCTGGGTGATATCGCACGCGCAAAAGGCATGTCGC
AGGTGGCTCGTGATGCCGGACTTTCCAGAGAAAGTCTTTATAAAGCCCTGTCAGGAGAACGAAGGCCAACCTTCGATACA
ATTCTTAAGGTGATCGGAGCACTTGGCCTAAAATTGCATGCGGAAGCGATTCATACAAATATCAATACGGGCCAACCTGT
CACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References