Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4422282..4422910 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN113_RS19275 Protein ID WP_155323569.1
Coordinates 4422282..4422683 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN113_RS19280 Protein ID WP_155323570.1
Coordinates 4422683..4422910 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS19255 4417593..4418408 + 816 WP_155320765.1 AAA family ATPase -
GN113_RS19260 4418399..4419370 + 972 WP_155320764.1 AAA family ATPase -
GN113_RS19265 4419367..4419813 + 447 WP_155323567.1 hypothetical protein -
GN113_RS19270 4420067..4421356 + 1290 WP_155323568.1 IS701 family transposase -
GN113_RS19275 4422282..4422683 - 402 WP_155323569.1 type II toxin-antitoxin system VapC family toxin Toxin
GN113_RS19280 4422683..4422910 - 228 WP_155323570.1 antitoxin Antitoxin
GN113_RS19285 4423081..4423464 + 384 WP_155323571.1 hypothetical protein -
GN113_RS19290 4423672..4423962 + 291 WP_155323572.1 type II toxin-antitoxin system RelE/ParE family toxin -
GN113_RS19295 4423972..4424298 + 327 WP_155313818.1 putative addiction module antidote protein -
GN113_RS19300 4424676..4424912 - 237 WP_155323573.1 type II toxin-antitoxin system YafQ family toxin -
GN113_RS19305 4424909..4425169 - 261 WP_155323574.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GN113_RS19310 4425345..4426655 - 1311 WP_155321603.1 ISL3 family transposase -
GN113_RS19315 4427269..4427907 + 639 WP_155323575.1 peptidoglycan-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15137.70 Da        Isoelectric Point: 8.4625

>T33430 WP_155323569.1 NZ_AP021876:c4422683-4422282 [Desulfosarcina ovata subsp. sediminis]
MKFMLDTNICIYIIKRKPPNVIDRFKRTEISQIGISSITLSELIYGVSKSSKPEQNRLALTQFVAPLEILPYDDEASQYY
GDLRVHLEKQGTPIGALDMLIAAHAISIDCTLVTNNEKEFIRVPKLKIVNWTK

Download         Length: 402 bp

>T33430 NZ_AP021876:c4422683-4422282 [Desulfosarcina ovata subsp. sediminis]
ATGAAATTCATGCTCGATACAAACATCTGTATTTATATAATCAAAAGAAAGCCTCCCAATGTTATAGACCGTTTCAAACG
AACCGAAATTTCGCAAATAGGTATCTCGTCGATTACCCTGAGTGAACTAATATATGGTGTCTCAAAAAGTTCTAAGCCCG
AACAAAACAGATTGGCTTTAACACAGTTTGTCGCGCCATTAGAAATTTTGCCCTATGACGATGAAGCGTCTCAATATTAT
GGCGATCTAAGAGTCCATTTGGAAAAGCAAGGGACACCTATTGGTGCACTTGATATGCTTATCGCCGCCCATGCGATTTC
AATTGACTGCACTCTGGTCACCAACAACGAAAAAGAATTTATTCGAGTACCGAAATTAAAAATAGTTAACTGGACCAAAT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8738.87 Da        Isoelectric Point: 6.2514

>AT33430 WP_155323570.1 NZ_AP021876:c4422910-4422683 [Desulfosarcina ovata subsp. sediminis]
MQTAKLFFNGRSQAVRLPKNLRFSGNDVFIRKLGKMVVLIPKDDPWSSLINSLDQFTDDFMDSRNQPDQDSREDF

Download         Length: 228 bp

>AT33430 NZ_AP021876:c4422910-4422683 [Desulfosarcina ovata subsp. sediminis]
ATGCAAACTGCGAAACTCTTTTTTAATGGTCGAAGCCAGGCGGTAAGGTTACCGAAAAACCTCAGATTTTCTGGCAATGA
TGTTTTTATCAGAAAACTCGGCAAGATGGTTGTCCTTATCCCAAAAGACGACCCTTGGTCATCACTCATCAATAGTCTTG
ATCAATTTACAGATGATTTTATGGATAGCAGAAATCAACCTGACCAAGATTCTCGAGAAGACTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References