Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2039313..2039930 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN113_RS09425 Protein ID WP_155322060.1
Coordinates 2039313..2039690 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN113_RS09430 Protein ID WP_155322061.1
Coordinates 2039700..2039930 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS09400 2034764..2036179 - 1416 WP_155322058.1 sugar transferase -
GN113_RS09405 2037016..2037390 - 375 WP_155322059.1 GxxExxY protein -
GN113_RS09410 2038015..2038236 - 222 WP_155309849.1 type II toxin-antitoxin system HicA family toxin -
GN113_RS09415 2038233..2038544 - 312 WP_197910443.1 type II toxin-antitoxin system HicB family antitoxin -
GN113_RS09420 2038811..2039191 - 381 WP_155309850.1 GxxExxY protein -
GN113_RS09425 2039313..2039690 - 378 WP_155322060.1 PIN domain-containing protein Toxin
GN113_RS09430 2039700..2039930 - 231 WP_155322061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GN113_RS09435 2040677..2041432 - 756 WP_155322062.1 hypothetical protein -
GN113_RS09440 2041890..2042042 - 153 WP_155314178.1 HEPN domain-containing protein -
GN113_RS09445 2042073..2042501 - 429 WP_173179259.1 nucleotidyltransferase domain-containing protein -
GN113_RS09450 2042726..2043085 - 360 WP_155322064.1 four helix bundle protein -
GN113_RS09455 2043138..2043566 - 429 WP_155322065.1 DUF86 domain-containing protein -
GN113_RS09460 2044279..2044761 - 483 WP_155309857.1 antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-116)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13969.28 Da        Isoelectric Point: 8.4919

>T33425 WP_155322060.1 NZ_AP021876:c2039690-2039313 [Desulfosarcina ovata subsp. sediminis]
ICIYTIKKKPPSVLKRLEMCQTGAVVMSAVTFAELMNGAKKSRWVDDNVRRLNALSELIEVLAFDRDAAVVYGDVRSDLE
KRGLVIGGNDLFIAAHALSLGYPLVTNNQREFSRVKGLMIDNWLE

Download         Length: 378 bp

>T33425 NZ_AP021876:c2039690-2039313 [Desulfosarcina ovata subsp. sediminis]
ATTTGCATTTATACGATAAAAAAGAAGCCTCCCAGTGTCTTGAAACGGCTCGAAATGTGCCAGACCGGCGCTGTGGTCAT
GTCAGCTGTAACGTTTGCGGAATTAATGAACGGCGCAAAAAAAAGTCGTTGGGTTGATGACAATGTTCGCCGGTTGAATG
CCCTGAGCGAGCTTATCGAGGTTCTTGCCTTTGACAGAGATGCCGCCGTGGTTTACGGAGATGTCCGCTCAGATCTTGAA
AAAAGAGGACTGGTCATCGGCGGCAACGATCTGTTTATCGCTGCGCATGCGTTAAGTCTGGGCTATCCCCTGGTGACCAA
TAACCAAAGGGAGTTCAGTCGGGTCAAGGGTTTAATGATCGATAACTGGTTGGAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8922.25 Da        Isoelectric Point: 6.3272

>AT33425 WP_155322061.1 NZ_AP021876:c2039930-2039700 [Desulfosarcina ovata subsp. sediminis]
METAKIFKSGNSQAVRLPKAFRFDVTEVQIFRRGDEVVLKRKPQNLSRVFELLTEMSDDFMEEGRCQPSMQEREPI

Download         Length: 231 bp

>AT33425 NZ_AP021876:c2039930-2039700 [Desulfosarcina ovata subsp. sediminis]
ATGGAAACCGCAAAAATTTTCAAAAGTGGCAACTCCCAAGCGGTCCGGCTGCCCAAAGCGTTCCGGTTCGATGTCACGGA
AGTCCAGATCTTTCGCAGAGGCGACGAAGTGGTATTGAAACGAAAACCGCAAAATCTGTCCAGAGTGTTCGAGCTTTTAA
CCGAAATGTCGGATGATTTCATGGAAGAGGGACGCTGCCAACCGTCGATGCAGGAAAGAGAACCGATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References