Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1994434..1995009 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GN113_RS09200 Protein ID WP_155322019.1
Coordinates 1994434..1994733 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GN113_RS09205 Protein ID WP_155322020.1
Coordinates 1994737..1995009 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS09175 1989567..1990877 - 1311 WP_155321603.1 ISL3 family transposase -
GN113_RS09180 1990915..1991916 - 1002 WP_155322023.1 transposase -
GN113_RS09185 1992343..1993275 - 933 WP_155322024.1 transposase -
GN113_RS37225 1993376..1993534 - 159 WP_197910547.1 hypothetical protein -
GN113_RS09195 1993472..1993802 + 331 Protein_1829 ATP-binding protein -
GN113_RS09200 1994434..1994733 + 300 WP_155322019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN113_RS09205 1994737..1995009 + 273 WP_155322020.1 putative addiction module antidote protein Antitoxin
GN113_RS09210 1995175..1995510 + 336 WP_155322026.1 HEPN domain-containing protein -
GN113_RS09215 1995480..1995788 + 309 WP_155322027.1 nucleotidyltransferase domain-containing protein -
GN113_RS09220 1996617..1998065 - 1449 WP_155322028.1 DUF362 domain-containing protein -
GN113_RS09225 1998043..1998441 - 399 WP_155322029.1 GtrA family protein -
GN113_RS09230 1998459..1999208 - 750 WP_155322030.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1967029..1995009 27980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(4-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11614.31 Da        Isoelectric Point: 10.1348

>T33424 WP_155322019.1 NZ_AP021876:1994434-1994733 [Desulfosarcina ovata subsp. sediminis]
MKYELRSTDQFDKWLSKLKDRSVRIKVLARLDRIENGNFGDCKQIGRDLFELRFFFGSGLRIYYTVKTNTVVFLLTGGNK
STQSRDIERATQILQTLED

Download         Length: 300 bp

>T33424 NZ_AP021876:1994434-1994733 [Desulfosarcina ovata subsp. sediminis]
ATGAAATACGAACTCCGTAGCACCGATCAATTCGACAAATGGCTTTCCAAACTGAAAGATCGTTCTGTAAGGATAAAGGT
GCTTGCCAGACTCGACAGGATCGAAAACGGCAACTTCGGAGACTGCAAGCAAATCGGCCGGGACCTGTTCGAGCTACGGT
TCTTTTTCGGTTCCGGCTTGCGAATTTACTACACTGTCAAGACAAACACGGTTGTTTTCCTGCTCACCGGTGGGAATAAA
TCCACCCAAAGCAGGGACATTGAAAGAGCAACCCAGATTTTGCAGACGCTGGAGGATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9787.09 Da        Isoelectric Point: 5.6851

>AT33424 WP_155322020.1 NZ_AP021876:1994737-1995009 [Desulfosarcina ovata subsp. sediminis]
MITKPFDIAEHLESTEDIRDFLNEVAQTGDEADFIHALNTAARAMGMSEVAKKAGVTRASLYKSLSENGNPRFDTISKVT
KALGCRLTVA

Download         Length: 273 bp

>AT33424 NZ_AP021876:1994737-1995009 [Desulfosarcina ovata subsp. sediminis]
TTGATCACAAAACCATTCGATATAGCCGAACACTTGGAATCGACGGAGGATATCCGCGATTTCCTTAACGAGGTGGCGCA
AACCGGCGATGAGGCCGATTTTATCCATGCATTGAATACGGCCGCCAGGGCGATGGGAATGAGCGAGGTCGCTAAAAAAG
CGGGCGTTACCAGGGCGAGTCTTTATAAATCCCTTTCCGAAAATGGAAACCCCAGGTTCGACACCATCAGCAAGGTGACC
AAAGCGCTCGGCTGCCGACTTACCGTAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References