Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1986903..1987478 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GN113_RS09155 Protein ID WP_155322019.1
Coordinates 1986903..1987202 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GN113_RS09160 Protein ID WP_155322020.1
Coordinates 1987206..1987478 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS09135 1982444..1983415 + 972 WP_155320764.1 AAA family ATPase -
GN113_RS09140 1983412..1984347 + 936 WP_155320763.1 toprim domain-containing protein -
GN113_RS09145 1984530..1985318 - 789 WP_155322018.1 DDE-type integrase/transposase/recombinase -
GN113_RS09150 1985396..1985902 - 507 WP_155320857.1 hypothetical protein -
GN113_RS09155 1986903..1987202 + 300 WP_155322019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN113_RS09160 1987206..1987478 + 273 WP_155322020.1 putative addiction module antidote protein Antitoxin
GN113_RS09165 1987741..1988619 + 879 WP_155322021.1 exosortase/archaeosortase family protein -
GN113_RS09170 1988598..1989224 + 627 WP_155322022.1 EpsI family protein -
GN113_RS09175 1989567..1990877 - 1311 WP_155321603.1 ISL3 family transposase -
GN113_RS09180 1990915..1991916 - 1002 WP_155322023.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1967029..1995009 27980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(4-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11614.31 Da        Isoelectric Point: 10.1348

>T33423 WP_155322019.1 NZ_AP021876:1986903-1987202 [Desulfosarcina ovata subsp. sediminis]
MKYELRSTDQFDKWLSKLKDRSVRIKVLARLDRIENGNFGDCKQIGRDLFELRFFFGSGLRIYYTVKTNTVVFLLTGGNK
STQSRDIERATQILQTLED

Download         Length: 300 bp

>T33423 NZ_AP021876:1986903-1987202 [Desulfosarcina ovata subsp. sediminis]
ATGAAATACGAACTCCGTAGCACCGATCAATTCGACAAATGGCTTTCCAAACTGAAAGATCGTTCTGTAAGGATAAAGGT
GCTTGCCAGACTCGACAGGATCGAAAACGGCAACTTCGGAGACTGCAAGCAAATCGGCCGGGACCTGTTCGAGCTACGGT
TCTTTTTCGGTTCCGGCTTGCGAATTTACTACACTGTCAAGACAAACACGGTTGTTTTCCTGCTCACCGGTGGGAATAAA
TCCACCCAAAGCAGGGACATTGAAAGAGCAACCCAGATTTTGCAGACGCTGGAGGATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9787.09 Da        Isoelectric Point: 5.6851

>AT33423 WP_155322020.1 NZ_AP021876:1987206-1987478 [Desulfosarcina ovata subsp. sediminis]
MITKPFDIAEHLESTEDIRDFLNEVAQTGDEADFIHALNTAARAMGMSEVAKKAGVTRASLYKSLSENGNPRFDTISKVT
KALGCRLTVA

Download         Length: 273 bp

>AT33423 NZ_AP021876:1987206-1987478 [Desulfosarcina ovata subsp. sediminis]
TTGATCACAAAACCATTCGATATAGCCGAACACTTGGAATCGACGGAGGATATCCGCGATTTCCTTAACGAGGTGGCGCA
AACCGGCGATGAGGCCGATTTTATCCATGCATTGAATACGGCCGCCAGGGCGATGGGAATGAGCGAGGTCGCTAAAAAAG
CGGGTGTTACCAGGGCGAGTCTTTATAAATCCCTTTCCGAAAATGGAAACCCCAGGTTCGACACCATCAGCAAGGTGACC
AAAGCGCTCGGCTGCCGACTTACCGTAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References