Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 913862..914520 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN113_RS04275 Protein ID WP_155309107.1
Coordinates 913862..914260 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN113_RS04280 Protein ID WP_155309108.1
Coordinates 914290..914520 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS04225 908919..909206 - 288 WP_155309098.1 DUF1778 domain-containing protein -
GN113_RS04230 909321..909581 - 261 WP_197910407.1 DUF86 domain-containing protein -
GN113_RS04235 909608..910033 - 426 WP_155309100.1 nucleotidyltransferase domain-containing protein -
GN113_RS04240 910182..910487 - 306 WP_155314130.1 nucleotidyltransferase domain-containing protein -
GN113_RS04245 910493..910930 - 438 WP_155309101.1 nucleotidyltransferase substrate binding protein -
GN113_RS04250 910927..911214 - 288 WP_155309102.1 hypothetical protein -
GN113_RS04255 911510..912376 - 867 WP_155321294.1 dTDP-4-dehydrorhamnose reductase -
GN113_RS04260 912592..912840 + 249 WP_155309104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GN113_RS04265 912841..913176 + 336 WP_155321295.1 type II toxin-antitoxin system PemK/MazF family toxin -
GN113_RS04270 913288..913848 - 561 WP_155321296.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
GN113_RS04275 913862..914260 - 399 WP_155309107.1 type II toxin-antitoxin system VapC family toxin Toxin
GN113_RS04280 914290..914520 - 231 WP_155309108.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GN113_RS04285 914589..915479 - 891 WP_155321297.1 glucose-1-phosphate thymidylyltransferase RfbA -
GN113_RS04290 915476..916555 - 1080 WP_155309110.1 dTDP-glucose 4,6-dehydratase -
GN113_RS04295 916595..917176 - 582 WP_155309111.1 winged helix-turn-helix transcriptional regulator -
GN113_RS04300 917451..917735 - 285 WP_155309112.1 helix-hairpin-helix domain-containing protein -
GN113_RS04305 918115..919470 + 1356 WP_155321298.1 sigma-54 dependent transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-42)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15613.12 Da        Isoelectric Point: 5.9817

>T33420 WP_155309107.1 NZ_AP021876:c914260-913862 [Desulfosarcina ovata subsp. sediminis]
MASKRGYLIDTHCWLWWHIEPSKLSRKVIELVEDGSTTIFFSVVSAWEIVIKYRLQKLRLPLNPYEYIPKRLEISYMDVL
PVQLEHTLQVENLPDHHKDPFDRLLIAQAISEKLNLISSDCQMSSYDVEIVW

Download         Length: 399 bp

>T33420 NZ_AP021876:c914260-913862 [Desulfosarcina ovata subsp. sediminis]
ATGGCAAGTAAAAGGGGCTATCTGATCGATACGCATTGCTGGCTGTGGTGGCATATTGAACCAAGCAAACTTAGCCGCAA
GGTCATCGAGCTCGTCGAGGACGGGAGCACAACCATTTTTTTTTCAGTGGTCAGTGCATGGGAAATTGTCATCAAATATA
GGTTGCAAAAGTTGAGACTCCCCTTGAATCCCTACGAATACATCCCAAAGCGTTTGGAGATAAGTTACATGGATGTGCTG
CCAGTCCAACTCGAACATACGTTGCAGGTTGAAAACCTGCCGGACCATCATAAGGATCCTTTTGACCGGCTGCTGATTGC
CCAAGCAATTTCAGAAAAATTGAACCTTATTTCCAGCGATTGTCAAATGTCATCTTACGATGTTGAGATCGTCTGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8501.88 Da        Isoelectric Point: 10.0971

>AT33420 WP_155309108.1 NZ_AP021876:c914520-914290 [Desulfosarcina ovata subsp. sediminis]
MLTINTHEAKTQLSRLLVRVSNGEEIIIAKSGKAVAKLVPIKRHTIKRKSGIDKGKGWIADDFDSPLPEELQAYFE

Download         Length: 231 bp

>AT33420 NZ_AP021876:c914520-914290 [Desulfosarcina ovata subsp. sediminis]
ATGCTAACAATAAATACCCATGAGGCAAAAACGCAGCTATCGCGTTTATTGGTCCGGGTAAGCAATGGCGAGGAGATCAT
CATTGCCAAATCTGGCAAAGCGGTTGCAAAGTTAGTCCCGATTAAGCGCCACACGATTAAACGTAAATCCGGTATCGATA
AGGGCAAGGGCTGGATCGCCGATGATTTTGACTCCCCACTGCCCGAAGAACTGCAAGCCTATTTTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References