Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 912592..913176 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GN113_RS04265 Protein ID WP_155321295.1
Coordinates 912841..913176 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GN113_RS04260 Protein ID WP_155309104.1
Coordinates 912592..912840 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS04215 907913..908212 - 300 WP_155321293.1 DUF86 domain-containing protein -
GN113_RS04220 908422..908922 - 501 WP_155309097.1 GNAT family N-acetyltransferase -
GN113_RS04225 908919..909206 - 288 WP_155309098.1 DUF1778 domain-containing protein -
GN113_RS04230 909321..909581 - 261 WP_197910407.1 DUF86 domain-containing protein -
GN113_RS04235 909608..910033 - 426 WP_155309100.1 nucleotidyltransferase domain-containing protein -
GN113_RS04240 910182..910487 - 306 WP_155314130.1 nucleotidyltransferase domain-containing protein -
GN113_RS04245 910493..910930 - 438 WP_155309101.1 nucleotidyltransferase substrate binding protein -
GN113_RS04250 910927..911214 - 288 WP_155309102.1 hypothetical protein -
GN113_RS04255 911510..912376 - 867 WP_155321294.1 dTDP-4-dehydrorhamnose reductase -
GN113_RS04260 912592..912840 + 249 WP_155309104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GN113_RS04265 912841..913176 + 336 WP_155321295.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GN113_RS04270 913288..913848 - 561 WP_155321296.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
GN113_RS04275 913862..914260 - 399 WP_155309107.1 type II toxin-antitoxin system VapC family toxin -
GN113_RS04280 914290..914520 - 231 WP_155309108.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GN113_RS04285 914589..915479 - 891 WP_155321297.1 glucose-1-phosphate thymidylyltransferase RfbA -
GN113_RS04290 915476..916555 - 1080 WP_155309110.1 dTDP-glucose 4,6-dehydratase -
GN113_RS04295 916595..917176 - 582 WP_155309111.1 winged helix-turn-helix transcriptional regulator -
GN113_RS04300 917451..917735 - 285 WP_155309112.1 helix-hairpin-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-107)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12339.25 Da        Isoelectric Point: 9.1887

>T33419 WP_155321295.1 NZ_AP021876:912841-913176 [Desulfosarcina ovata subsp. sediminis]
MTAYVPKQGDIIAISFDPPSGHEQKGRRPALVVSKDLFNRSTGLAIVCPVTNTDRGFPFHVAIPRNSKLTGFIMVEQVKS
VDFRARRAKRIEHGNDELLSEVLSILDACIY

Download         Length: 336 bp

>T33419 NZ_AP021876:912841-913176 [Desulfosarcina ovata subsp. sediminis]
ATGACTGCTTATGTCCCGAAGCAAGGGGACATCATCGCTATCTCATTTGATCCCCCATCCGGTCATGAGCAGAAGGGTCG
TCGCCCGGCCTTGGTTGTCAGCAAAGACCTGTTTAATCGAAGCACTGGTTTGGCCATAGTCTGCCCGGTTACGAACACGG
ATCGTGGTTTCCCCTTTCATGTCGCTATTCCGCGAAACAGCAAGCTGACAGGTTTTATTATGGTTGAGCAGGTTAAATCT
GTTGATTTCCGCGCTCGTCGAGCTAAACGAATCGAGCATGGCAATGATGAATTGCTGTCCGAGGTGCTGTCCATACTGGA
TGCCTGCATCTATTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9164.62 Da        Isoelectric Point: 9.7674

>AT33419 WP_155309104.1 NZ_AP021876:912592-912840 [Desulfosarcina ovata subsp. sediminis]
MLAKIQKWGNSQGLRLAKNLLADAKLGVGDEVDIRVKDGIMIVTPTQKIRGKHRLEDLVARIPENYQPGEANWGEPMGKE
AW

Download         Length: 249 bp

>AT33419 NZ_AP021876:912592-912840 [Desulfosarcina ovata subsp. sediminis]
ATGCTTGCAAAAATTCAGAAATGGGGCAATAGCCAAGGCCTTCGCCTTGCTAAGAATCTACTTGCAGATGCAAAACTAGG
CGTTGGTGACGAGGTGGATATCCGTGTCAAAGACGGTATTATGATCGTTACACCGACCCAAAAGATTCGTGGTAAGCACA
GGCTTGAGGATCTTGTCGCACGGATTCCTGAAAATTACCAGCCCGGTGAAGCCAACTGGGGAGAGCCGATGGGTAAGGAG
GCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References