Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 909321..910033 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag GN113_RS04230 Protein ID WP_197910407.1
Coordinates 909321..909581 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag GN113_RS04235 Protein ID WP_155309100.1
Coordinates 909608..910033 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS04195 905071..906198 - 1128 Protein_831 putative DNA binding domain-containing protein -
GN113_RS04200 906474..906896 - 423 WP_155321291.1 nucleotidyltransferase domain-containing protein -
GN113_RS04205 906908..907327 - 420 WP_155309094.1 DUF86 domain-containing protein -
GN113_RS04210 907324..907746 - 423 WP_155321292.1 hypothetical protein -
GN113_RS04215 907913..908212 - 300 WP_155321293.1 DUF86 domain-containing protein -
GN113_RS04220 908422..908922 - 501 WP_155309097.1 GNAT family N-acetyltransferase -
GN113_RS04225 908919..909206 - 288 WP_155309098.1 DUF1778 domain-containing protein -
GN113_RS04230 909321..909581 - 261 WP_197910407.1 DUF86 domain-containing protein Toxin
GN113_RS04235 909608..910033 - 426 WP_155309100.1 nucleotidyltransferase domain-containing protein Antitoxin
GN113_RS04240 910182..910487 - 306 WP_155314130.1 nucleotidyltransferase domain-containing protein -
GN113_RS04245 910493..910930 - 438 WP_155309101.1 nucleotidyltransferase substrate binding protein -
GN113_RS04250 910927..911214 - 288 WP_155309102.1 hypothetical protein -
GN113_RS04255 911510..912376 - 867 WP_155321294.1 dTDP-4-dehydrorhamnose reductase -
GN113_RS04260 912592..912840 + 249 WP_155309104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GN113_RS04265 912841..913176 + 336 WP_155321295.1 type II toxin-antitoxin system PemK/MazF family toxin -
GN113_RS04270 913288..913848 - 561 WP_155321296.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
GN113_RS04275 913862..914260 - 399 WP_155309107.1 type II toxin-antitoxin system VapC family toxin -
GN113_RS04280 914290..914520 - 231 WP_155309108.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(6-79)

Antitoxin

Polymerase beta, nucleotidyltransferase

(16-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9818.47 Da        Isoelectric Point: 9.9383

>T33418 WP_197910407.1 NZ_AP021876:c909581-909321 [Desulfosarcina ovata subsp. sediminis]
MSGACHLVRVRKLGVPQESRDAFDMLGEADLLKPVLRDRLKSMVGFRNVAVHGYRKLNIEIVRTIVETRLGDFREFAKVV
LQEGHE

Download         Length: 261 bp

>T33418 NZ_AP021876:c909581-909321 [Desulfosarcina ovata subsp. sediminis]
TTGAGCGGTGCCTGTCATCTCGTCCGGGTGCGTAAATTGGGGGTGCCGCAGGAATCCAGAGACGCTTTCGATATGCTTGG
CGAAGCTGACCTGTTGAAACCGGTATTGCGTGATCGCCTCAAGTCGATGGTCGGATTCCGCAATGTTGCTGTACACGGCT
ATCGCAAACTGAACATTGAAATTGTTCGTACCATTGTTGAAACACGCCTTGGTGATTTCCGCGAGTTCGCCAAAGTGGTA
TTGCAGGAAGGGCATGAGTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15725.85 Da        Isoelectric Point: 4.7851

>AT33418 WP_155309100.1 NZ_AP021876:c910033-909608 [Desulfosarcina ovata subsp. sediminis]
MSLNVLLNSQLQKELIEEICSTVHSCVAIYRFGSWGTAAQRKGSDIDIAVLAASPLDPVGRWDLAQKLASIAGRDVDLVD
LLRASTVLRMQVVAYGERLHCVDAEAAERFEDNVFSSYAKLNEERRLILEDVNRRGSVYDQ

Download         Length: 426 bp

>AT33418 NZ_AP021876:c910033-909608 [Desulfosarcina ovata subsp. sediminis]
ATGTCGCTGAATGTGTTGTTGAATTCACAATTGCAGAAGGAACTTATTGAAGAGATCTGCTCCACTGTCCACAGTTGTGT
GGCGATTTATCGCTTTGGCTCATGGGGCACGGCTGCTCAGAGAAAAGGGAGCGATATAGACATTGCCGTCTTGGCTGCAT
CGCCGCTTGATCCGGTTGGTCGTTGGGATCTTGCCCAGAAATTGGCATCAATAGCTGGTCGGGATGTTGACCTGGTCGAT
TTGCTGAGGGCTTCAACGGTTTTACGTATGCAGGTGGTGGCGTATGGTGAGCGGCTTCATTGTGTTGATGCCGAAGCGGC
TGAACGTTTTGAAGATAACGTATTTTCCAGCTATGCCAAGCTCAATGAGGAGCGCCGCTTGATTCTTGAGGATGTGAATA
GGCGAGGGAGTGTGTATGACCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References