Detailed information of TA system TA033417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 511294..511868
• Replicon: chromosome
• Accession: NZ_AP021876
• Organism: Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GN113_RS02420
• Protein ID: WP_155308698.1
• Coordinates: 511294..511590 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GN113_RS02425
• Protein ID: WP_155321007.1
• Coordinates: 511587..511868 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN113_RS02405	506593..507780	-	1188	WP_155321005.1	12,18-didecarboxysiroheme deacetylase	-
GN113_RS02410	507787..509571	-	1785	WP_155321006.1	AAA family ATPase	-
GN113_RS02415	510113..511087	+	975	WP_155308697.1	PHP domain-containing protein	-
GN113_RS02420	511294..511590	-	297	WP_155308698.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GN113_RS02425	511587..511868	-	282	WP_155321007.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GN113_RS02430	512644..513477	-	834	WP_155321008.1	Retron-type reverse transcriptase	-
GN113_RS02435	513458..514474	-	1017	WP_155308703.1	CRISPR-associated endonuclease Cas1	-
GN113_RS02440	514471..514800	-	330	WP_173179020.1	CRISPR-associated endonuclease Cas2	-
GN113_RS02445	514850..515134	-	285	WP_155308705.1	CRISPR-associated endonuclease Cas2	-
GN113_RS02450	515185..515733	-	549	WP_155321010.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11384.29 Da
• Isoelectric Point: 5.8717

>T33417 WP_155308698.1 NZ_AP021876:c511590-511294 [Desulfosarcina ovata subsp. sediminis]
MKIVWSPLAIERASEIAEYIAQDKPSAAEKWLDTIFTKVETLKSAPEIGRVVPEIRNSQFRDLIYGNYRIIYRIEEKQIS
ILTIRHGMQILPIDEILV

Nucleotide

• Length: 297 bp

>T33417 NZ_AP021876:c511590-511294 [Desulfosarcina ovata subsp. sediminis]
ATGAAAATAGTTTGGTCTCCGTTAGCCATTGAACGGGCATCAGAAATTGCCGAATATATTGCTCAAGATAAACCATCAGC
TGCAGAAAAATGGCTTGACACAATCTTTACCAAGGTAGAGACGCTAAAATCCGCTCCCGAAATTGGAAGAGTTGTTCCTG
AAATTCGAAATAGTCAATTTCGGGATCTAATTTATGGTAATTACAGAATTATATACCGTATTGAAGAGAAGCAGATATCT
ATTCTTACGATTCGCCACGGCATGCAGATACTACCGATCGATGAGATTCTGGTATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10686.34 Da
• Isoelectric Point: 7.4033

>AT33417 WP_155321007.1 NZ_AP021876:c511868-511587 [Desulfosarcina ovata subsp. sediminis]
MQRLKISQDIKPLSEFRTGIANFIKQVHDTKRPVIITQHGKGVAVLLDVHEYETMQEKLELLSDVQISLNQLENGEGVLH
EDAKQSILRRIQK

Nucleotide

• Length: 282 bp

>AT33417 NZ_AP021876:c511868-511587 [Desulfosarcina ovata subsp. sediminis]
ATGCAAAGATTAAAAATCAGTCAGGATATCAAACCTTTGTCCGAATTTAGGACTGGTATAGCGAATTTTATTAAACAAGT
TCATGATACAAAACGACCAGTTATCATTACTCAGCATGGAAAGGGAGTTGCGGTTTTATTGGATGTTCATGAATATGAAA
CAATGCAGGAGAAACTCGAACTTCTGTCAGACGTCCAAATATCACTAAACCAACTCGAAAATGGTGAAGGGGTTCTTCAT
GAAGATGCAAAGCAAAGCATCCTCAGAAGGATTCAAAAATGA