Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 434945..435590 Replicon chromosome
Accession NZ_AP021875
Organism Desulfosarcina widdelii strain PP31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN111_RS02070 Protein ID WP_155302155.1
Coordinates 434945..435370 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN111_RS02075 Protein ID WP_155302156.1
Coordinates 435357..435590 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN111_RS02030 430669..430893 - 225 WP_155302147.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GN111_RS02035 430895..431287 - 393 WP_155302148.1 type II toxin-antitoxin system VapC family toxin -
GN111_RS02040 431755..431937 + 183 WP_155302149.1 type II toxin-antitoxin system HicA family toxin -
GN111_RS02045 431943..432161 + 219 WP_155302150.1 type II toxin-antitoxin system HicB family antitoxin -
GN111_RS02050 432566..432886 - 321 WP_155302151.1 nucleotidyltransferase domain-containing protein -
GN111_RS02055 432865..433245 - 381 WP_155302152.1 HEPN domain-containing protein -
GN111_RS02060 433487..434266 - 780 WP_155302153.1 transposase -
GN111_RS02065 434367..434606 - 240 WP_155302154.1 DUF433 domain-containing protein -
GN111_RS02070 434945..435370 - 426 WP_155302155.1 PIN domain-containing protein Toxin
GN111_RS02075 435357..435590 - 234 WP_155302156.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GN111_RS02080 435802..436203 - 402 WP_155302157.1 PIN domain-containing protein -
GN111_RS02085 436200..436493 - 294 WP_155302158.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GN111_RS02090 436991..437917 - 927 WP_155302159.1 hypothetical protein -
GN111_RS02095 438140..438505 - 366 WP_197740481.1 type II toxin-antitoxin system PemK/MazF family toxin -
GN111_RS02100 438495..438743 - 249 WP_155302160.1 hypothetical protein -
GN111_RS02105 439046..439921 + 876 WP_155302161.1 glucose-1-phosphate thymidylyltransferase RfbA -
GN111_RS33500 439902..440333 - 432 WP_176603277.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 378487..442467 63980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15789.17 Da        Isoelectric Point: 4.5901

>T33414 WP_155302155.1 NZ_AP021875:c435370-434945 [Desulfosarcina widdelii]
MPANKSFIDTNVLIYLLSADSVKADRAEEIVLNGGIISVQVLNELTNVALRKLGMPWPEINDFLSLIRFVCPVEPLTLET
HDCGRHVAEHYKLSVYDSMIVAAALMAGCNTLYSEDMHDGLLIDEQVRVFNPFRPEFSQAH

Download         Length: 426 bp

>T33414 NZ_AP021875:c435370-434945 [Desulfosarcina widdelii]
ATGCCCGCCAATAAATCGTTTATCGACACTAACGTATTGATCTATTTATTGTCGGCGGATTCAGTGAAAGCTGATCGTGC
TGAGGAGATCGTCCTCAACGGCGGTATCATCAGTGTACAAGTGCTCAACGAGCTTACCAATGTAGCGTTACGAAAGTTGG
GCATGCCCTGGCCGGAGATCAATGACTTTTTGTCTCTGATCCGATTTGTTTGCCCGGTGGAGCCGTTAACCTTAGAAACG
CATGATTGCGGCAGACATGTTGCCGAGCATTACAAATTAAGCGTGTACGACTCGATGATCGTGGCTGCTGCACTTATGGC
AGGATGCAACACCCTGTATTCTGAAGACATGCATGATGGCTTGCTGATTGATGAGCAGGTGCGCGTCTTTAACCCATTCC
GACCAGAATTTTCCCAGGCCCATTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8671.03 Da        Isoelectric Point: 10.4004

>AT33414 WP_155302156.1 NZ_AP021875:c435590-435357 [Desulfosarcina widdelii]
MQVSKWGNSLAIRLPAAVVSALDLNEGDDIEVIVADERVFKVRKKPGKEAFLAKLRKYRGKLPADFIFDRNDANARQ

Download         Length: 234 bp

>AT33414 NZ_AP021875:c435590-435357 [Desulfosarcina widdelii]
ATGCAAGTATCCAAATGGGGAAACAGTCTGGCGATCCGTTTGCCCGCAGCTGTAGTCAGTGCCCTGGACCTGAATGAAGG
TGATGATATCGAGGTGATCGTTGCCGATGAACGGGTATTCAAGGTAAGAAAGAAACCCGGAAAAGAGGCATTTCTGGCAA
AACTGAGGAAATACCGTGGGAAACTACCCGCAGACTTCATCTTTGACCGGAATGACGCCAATGCCCGCCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References