Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4479873..4480496 Replicon chromosome
Accession NZ_AP021874
Organism Desulfosarcina alkanivorans strain PL12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DSCA_RS19590 Protein ID WP_167528071.1
Coordinates 4480299..4480496 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DSCA_RS19585 Protein ID WP_155318033.1
Coordinates 4479873..4480289 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSCA_RS19565 4476067..4476540 - 474 WP_155318029.1 DUF4411 family protein -
DSCA_RS19570 4476540..4477757 - 1218 WP_155318030.1 XRE family transcriptional regulator -
DSCA_RS19575 4478564..4478857 + 294 WP_155318031.1 type II toxin-antitoxin system RelE/ParE family toxin -
DSCA_RS19580 4478823..4479185 + 363 WP_155318032.1 HigA family addiction module antidote protein -
DSCA_RS19585 4479873..4480289 - 417 WP_155318033.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DSCA_RS19590 4480299..4480496 - 198 WP_167528071.1 type II toxin-antitoxin system HicA family toxin Toxin
DSCA_RS19595 4481071..4481385 - 315 WP_155318035.1 HigA family addiction module antidote protein -
DSCA_RS19600 4481397..4481678 - 282 WP_155320488.1 type II toxin-antitoxin system RelE/ParE family toxin -
DSCA_RS19605 4482020..4482481 + 462 WP_155318036.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
DSCA_RS19610 4482456..4482890 + 435 WP_155318037.1 DUF4405 domain-containing protein -
DSCA_RS19615 4483262..4484980 - 1719 WP_155318038.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-125)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7500.83 Da        Isoelectric Point: 11.5470

>T33411 WP_167528071.1 NZ_AP021874:c4480496-4480299 [Desulfosarcina alkanivorans]
IHTMNSRKIIQILKQNGWYEVAKVGSHTQFRHPQIKGRVTVPHPKKDLPIGTLKSIERQSGIKFK

Download         Length: 198 bp

>T33411 NZ_AP021874:c4480496-4480299 [Desulfosarcina alkanivorans]
ATACACACTATGAACAGCCGGAAAATCATTCAGATACTCAAACAAAACGGCTGGTACGAGGTTGCCAAAGTTGGTTCTCA
TACTCAATTCCGGCATCCACAAATAAAGGGGCGAGTTACCGTGCCACACCCTAAAAAGGATTTGCCGATAGGCACATTGA
AAAGCATCGAGCGCCAATCGGGAATTAAGTTCAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14927.82 Da        Isoelectric Point: 4.9264

>AT33411 WP_155318033.1 NZ_AP021874:c4480289-4479873 [Desulfosarcina alkanivorans]
MANYIAIVHKEAKSDFGVSFPDFPGCVTAGQTVDEAKDLAQEALALHINGMVEDGDQLPSPSKLEDIMADEDSAEAVAYL
VVSVPDTKPRTVRVNITVPEMTLKQIDAAAKKRGMSRSSFLVHLAQNEIHSHHSQQSA

Download         Length: 417 bp

>AT33411 NZ_AP021874:c4480289-4479873 [Desulfosarcina alkanivorans]
ATGGCAAATTATATCGCTATTGTTCACAAAGAGGCCAAATCTGATTTTGGCGTATCTTTTCCAGACTTTCCTGGTTGTGT
TACAGCCGGGCAAACCGTTGACGAGGCCAAGGATTTAGCCCAGGAGGCGCTTGCCCTCCATATAAACGGAATGGTTGAAG
ACGGCGATCAATTGCCGTCCCCGTCCAAACTTGAAGATATCATGGCTGATGAGGATTCCGCTGAGGCCGTCGCCTACCTT
GTTGTTTCTGTTCCGGATACCAAACCCCGCACCGTAAGGGTGAATATTACTGTACCAGAGATGACCCTTAAACAAATTGA
TGCAGCTGCAAAGAAACGGGGAATGTCAAGATCCTCCTTTCTCGTTCACCTCGCGCAGAATGAGATCCATTCACATCATT
CCCAGCAATCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References