Detailed information of TA system TA033410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1381901..1382535
• Replicon: chromosome
• Accession: NZ_AP021874
• Organism: Desulfosarcina alkanivorans strain PL12

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DSCA_RS06090
• Protein ID: WP_197904751.1
• Coordinates: 1381901..1382308 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DSCA_RS06095
• Protein ID: WP_155315582.1
• Coordinates: 1382305..1382535 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSCA_RS06060	1377086..1378345	-	1260	WP_155320325.1	MBL fold metallo-hydrolase	-
DSCA_RS06065	1378652..1379032	-	381	WP_155315577.1	GxxExxY protein	-
DSCA_RS06070	1379677..1379874	+	198	WP_155315578.1	type II toxin-antitoxin system VapB family antitoxin	-
DSCA_RS06075	1379871..1380248	+	378	WP_155315579.1	PIN domain-containing protein	-
DSCA_RS06080	1380671..1381087	-	417	WP_155315580.1	DUF86 domain-containing protein	-
DSCA_RS06085	1381080..1381496	-	417	WP_155315581.1	nucleotidyltransferase domain-containing protein	-
DSCA_RS06090	1381901..1382308	-	408	WP_197904751.1	type II toxin-antitoxin system VapC family toxin	Toxin
DSCA_RS06095	1382305..1382535	-	231	WP_155315582.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DSCA_RS06100	1382946..1383215	+	270	WP_155320327.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DSCA_RS06105	1383212..1383496	+	285	WP_155315583.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DSCA_RS06110	1384542..1384925	-	384	WP_155315584.1	GxxExxY protein	-
DSCA_RS06115	1385415..1387166	-	1752	WP_155315585.1	acyl--CoA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1320683..1397368	76685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15109.62 Da
• Isoelectric Point: 7.1673

>T33410 WP_197904751.1 NZ_AP021874:c1382308-1381901 [Desulfosarcina alkanivorans]
MTVMLDTDICIYTIKRKPISVLKRLEKVQPGMVVMSVITFAELINGAKKSQHVEANLRRLNALSELIDVLPFDKDAAMAY
GDVRSDLEKRGLIIGGNDLFIAAHALSLNLTLVTNNQREFGRVNGLKIENWVENE

Nucleotide

• Length: 408 bp

>T33410 NZ_AP021874:c1382308-1381901 [Desulfosarcina alkanivorans]
ATGACGGTCATGCTGGACACGGATATTTGCATTTACACGATTAAACGCAAACCAATCTCTGTCTTGAAACGACTCGAAAA
GGTCCAGCCCGGCATGGTTGTTATGTCCGTCATCACTTTTGCCGAATTAATCAACGGGGCCAAAAAAAGCCAGCATGTAG
AAGCAAACCTCAGGCGGTTAAACGCATTGAGTGAGCTTATCGACGTCTTACCTTTTGATAAGGATGCTGCCATGGCATAC
GGTGATGTCCGTTCTGACTTGGAAAAAAGAGGCCTGATCATTGGAGGCAATGACCTGTTTATCGCTGCCCATGCCCTGAG
CCTGAACCTGACATTGGTTACCAACAATCAAAGGGAATTCGGCCGGGTGAATGGATTAAAGATTGAAAATTGGGTCGAGA
ATGAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8819.07 Da
• Isoelectric Point: 7.9847

>AT33410 WP_155315582.1 NZ_AP021874:c1382535-1382305 [Desulfosarcina alkanivorans]
MDTAKIFRSGNSQAVRLPKAYQFDSSEVQIFRRGDEIILKRKPQNLARAFELLTEMSDDFMVQGRCQPSIQDREPL

Nucleotide

• Length: 231 bp

>AT33410 NZ_AP021874:c1382535-1382305 [Desulfosarcina alkanivorans]
ATGGATACCGCAAAAATATTCAGGAGCGGCAATTCCCAGGCGGTTCGGCTACCCAAGGCCTATCAGTTTGATTCTTCGGA
GGTGCAGATTTTTCGTCGGGGTGATGAAATTATTTTAAAGCGCAAACCGCAGAATCTGGCAAGAGCCTTCGAACTGCTAA
CCGAAATGTCTGATGACTTCATGGTTCAAGGGCGTTGTCAACCATCAATTCAAGACCGGGAACCCCTATGA