Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3802669..3803325 Replicon chromosome
Accession NZ_AP021873
Organism Serratia marcescens strain ATCC 274

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YUY4
Locus tag SMATCC274_RS18040 Protein ID WP_033639649.1
Coordinates 3802669..3803058 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YUX3
Locus tag SMATCC274_RS18045 Protein ID WP_033639648.1
Coordinates 3803062..3803325 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMATCC274_RS18025 3799137..3800567 + 1431 WP_060445283.1 multidrug transporter subunit MdtD -
SMATCC274_RS18030 3800564..3801946 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
SMATCC274_RS18035 3801946..3802662 + 717 WP_004941568.1 two-component system response regulator BaeR -
SMATCC274_RS18040 3802669..3803058 - 390 WP_033639649.1 type II toxin-antitoxin system VapC family toxin Toxin
SMATCC274_RS18045 3803062..3803325 - 264 WP_033639648.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMATCC274_RS18050 3803664..3804002 + 339 WP_016926703.1 YegP family protein -
SMATCC274_RS18055 3804181..3805533 + 1353 WP_028127781.1 tRNA 5-hydroxyuridine modification protein YegQ -
SMATCC274_RS18060 3806001..3806906 + 906 WP_016926701.1 lipid kinase YegS -
SMATCC274_RS18065 3807075..3808289 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 7.8794

>T33406 WP_033639649.1 NZ_AP021873:c3803058-3802669 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAIDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T33406 NZ_AP021873:c3803058-3802669 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGGAAGGGCAAAATCATGGGCGCGATCGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10094.37 Da        Isoelectric Point: 4.6702

>AT33406 WP_033639648.1 NZ_AP021873:c3803325-3803062 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGMADR
DPFSEEE

Download         Length: 264 bp

>AT33406 NZ_AP021873:c3803325-3803062 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGATGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YUY4

Antitoxin

Source ID Structure
AlphaFold DB A0A379YUX3

References