Detailed information of TA system TA033394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 55089..55567
• Replicon: chromosome
• Accession: NZ_AP021873
• Organism: Serratia marcescens strain ATCC 274

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SMATCC274_RS00235
• Protein ID: WP_161544284.1
• Coordinates: 55349..55567 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: SMATCC274_RS00230
• Protein ID: WP_033639076.1
• Coordinates: 55089..55349 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMATCC274_RS00210	50415..51065	+	651	WP_033639079.1	DcrB-related protein	-
SMATCC274_RS00215	51101..51706	+	606	WP_004934025.1	glutathione S-transferase	-
SMATCC274_RS00220	51774..53168	+	1395	WP_060444908.1	L-seryl-tRNA(Sec) selenium transferase	-
SMATCC274_RS00225	53165..55006	+	1842	WP_060444909.1	selenocysteine-specific translation elongation factor	-
SMATCC274_RS00230	55089..55349	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
SMATCC274_RS00235	55349..55567	+	219	WP_161544284.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMATCC274_RS00240	55636..56547	-	912	WP_033639075.1	LysR family transcriptional regulator	-
SMATCC274_RS00245	56669..57295	+	627	WP_033639074.1	LysE family translocator	-
SMATCC274_RS00250	57349..58596	-	1248	WP_028127797.1	MFS transporter	-
SMATCC274_RS00255	58814..59806	+	993	WP_161544285.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-72)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8200.59 Da
• Isoelectric Point: 10.2163

>T33394 WP_161544284.1 NZ_AP021873:55349-55567 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRY

Nucleotide

• Length: 219 bp

>T33394 NZ_AP021873:55349-55567 [Serratia marcescens]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT33394 WP_033639076.1 NZ_AP021873:55089-55349 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT33394 NZ_AP021873:55089-55349 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCACTGCCGGTACCGCGCTGA