Detailed information of TA system TA033393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 914642..915180
• Replicon: chromosome
• Accession: NZ_AP021870
• Organism: Vibrio gangliei strain DSM 104291

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Vgang_RS16200
• Protein ID: WP_105901064.1
• Coordinates: 914642..914941 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: Vgang_RS16205
• Protein ID: WP_105901065.1
• Coordinates: 914938..915180 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Vgang_RS16180	910645..911607	+	963	WP_105901060.1	ABC transporter permease	-
Vgang_RS16185	911604..912392	+	789	WP_105901061.1	ABC transporter permease	-
Vgang_RS16190	912396..913802	+	1407	WP_105901062.1	ATP-binding cassette domain-containing protein	-
Vgang_RS16195	913969..914517	+	549	WP_105901063.1	hypothetical protein	-
Vgang_RS16200	914642..914941	-	300	WP_105901064.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Vgang_RS16205	914938..915180	-	243	WP_105901065.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
Vgang_RS16210	915342..916727	-	1386	WP_105901066.1	PepSY-associated TM helix domain-containing protein	-
Vgang_RS16215	916756..917127	-	372	WP_264923603.1	DUF2946 domain-containing protein	-
Vgang_RS16220	917343..918605	+	1263	WP_105901068.1	MFS transporter	-
Vgang_RS16225	918602..919294	+	693	WP_105901069.1	peptidoglycan DD-metalloendopeptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11703.35 Da
• Isoelectric Point: 10.2231

>T33393 WP_105901064.1 NZ_AP021870:c914941-914642 [Vibrio gangliei]
MRPFQLTNKAKSDLRNIALFTSRRWGREQRNIYLKQFDDSFWQLAENPDIGKACDEVRDGYRKFPQGSHLIFYRQIGSQN
IEIIRILHKSMDVNPIFGG

Nucleotide

• Length: 300 bp

>T33393 NZ_AP021870:c914941-914642 [Vibrio gangliei]
ATGAGGCCATTTCAGTTAACAAACAAGGCGAAATCTGATTTAAGAAATATAGCCTTGTTTACCTCTCGACGCTGGGGTCG
TGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCAGTTAGCCGAAAACCCTGACATTGGTAAAGCCT
GTGATGAAGTTCGCGATGGATACAGAAAATTCCCCCAAGGCAGCCACCTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATTCTCCACAAAAGTATGGATGTAAATCCAATTTTTGGCGGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8925.86 Da
• Isoelectric Point: 4.2213

>AT33393 WP_105901065.1 NZ_AP021870:c915180-914938 [Vibrio gangliei]
MAKNTSITLGDHFDGFIASQIQNGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEEKK

Nucleotide

• Length: 243 bp

>AT33393 NZ_AP021870:c915180-914938 [Vibrio gangliei]
ATGGCTAAGAACACTAGCATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAGTCAAATTCAAAACGGTCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCCGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAATTGC
TTGTTGAAGGTGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCATTTATCAATGAGCTAGATAGCGAAGAGAAAAAA
TGA