Detailed information of TA system TA033392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 720033..720592
• Replicon: chromosome
• Accession: NZ_AP021870
• Organism: Vibrio gangliei strain DSM 104291

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Vgang_RS15310
• Protein ID: WP_105901694.1
• Coordinates: 720314..720592 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Vgang_RS15305
• Protein ID: WP_105901693.1
• Coordinates: 720033..720317 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Vgang_RS15290	716718..718352	+	1635	WP_245879886.1	malate synthase A	-
Vgang_RS15295	718482..718913	+	432	WP_105901820.1	heme-binding protein	-
Vgang_RS15300	719037..719771	+	735	WP_105901692.1	GntR family transcriptional regulator	-
Vgang_RS15305	720033..720317	+	285	WP_105901693.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
Vgang_RS15310	720314..720592	+	279	WP_105901694.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Vgang_RS15315	720599..720796	+	198	Protein_659	IS110 family transposase	-
Vgang_RS15320	721635..722801	-	1167	WP_105901696.1	adenosine deaminase	-
Vgang_RS15325	723252..724235	-	984	WP_105901697.1	rhodanese-related sulfurtransferase	-
Vgang_RS15330	724575..725000	+	426	WP_105901698.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	720617..720796	179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-68)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10975.69 Da
• Isoelectric Point: 4.2800

>T33392 WP_105901694.1 NZ_AP021870:720314-720592 [Vibrio gangliei]
VILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEDDIIRVM
RVLHQKQKFPME

Nucleotide

• Length: 279 bp

>T33392 NZ_AP021870:720314-720592 [Vibrio gangliei]
GTGATTTTATGGGAAGAGGAGTCACTTAATGATCGTGAAAAAATCTTTGAGTTTCTTTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAATCTCATTGAAGCTAAAGTAGAAAATTTGCTTGAGCAACCACTGATGGGAGTTCAGCGAGATGGCA
TTCGTGGACGATTACTCATTATTCCTGAGATTTCGATGATCATTTCTTACTGGGTCGAAGACGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTTCCTATGGAATAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11039.37 Da
• Isoelectric Point: 9.2167

>AT33392 WP_105901693.1 NZ_AP021870:720033-720317 [Vibrio gangliei]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNLAFDKFDSGKSIFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT33392 NZ_AP021870:720033-720317 [Vibrio gangliei]
ATGGACACTAGAATTCAATTTCGTGTTGATGAGGAAACAAAACGCCTAGCTCAACAGATGGCTGAAAGCCAAGGTCGCAC
ACTCAGCGATGCTTGCCGAGAGCTTACTGAGCAACTCGCTGAGCAACAAAGAAAAGCGTTATCTCACGATGCATGGTTAA
CTGAACAAGTAAACCTAGCATTTGATAAGTTTGACTCAGGAAAATCCATTTTCGTTGAACACCAAACCGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAGTGA