Detailed information of TA system TA033389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 576439..576986
• Replicon: chromosome
• Accession: NZ_AP021869
• Organism: Vibrio gangliei strain DSM 104291

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Vgang_RS02630
• Protein ID: WP_105902157.1
• Coordinates: 576684..576986 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Vgang_RS02625
• Protein ID: WP_105902158.1
• Coordinates: 576439..576696 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Vgang_RS02600	573361..573864	+	504	WP_105902163.1	signal peptidase II	-
Vgang_RS02605	574020..574448	+	429	WP_105902162.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
Vgang_RS02610	574538..575482	+	945	WP_105902161.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
Vgang_RS02615	575819..576289	+	471	WP_105902160.1	GNAT family N-acetyltransferase	-
Vgang_RS02620	576283..576417	+	135	WP_105902159.1	DUF3265 domain-containing protein	-
Vgang_RS02625	576439..576696	+	258	WP_105902158.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Vgang_RS02630	576684..576986	+	303	WP_105902157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Vgang_RS02635	577402..578892	-	1491	WP_105902156.1	carbon starvation protein A	-
Vgang_RS02640	579192..579545	+	354	WP_105902323.1	DUF2799 domain-containing protein	-
Vgang_RS02645	579589..581373	+	1785	WP_105902155.1	sodium:proton antiporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11734.61 Da
• Isoelectric Point: 4.8951

>T33389 WP_105902157.1 NZ_AP021869:576684-576986 [Vibrio gangliei]
MAEIIWTEPALSDLNDIAEYIALENVMAAKQLVQTIFSKVERLETFPESGRIPPELEHLSYREVVVNPCRVFYKQDSDKV
YILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T33389 NZ_AP021869:576684-576986 [Vibrio gangliei]
ATGGCTGAAATAATCTGGACTGAGCCGGCTCTATCTGACCTCAATGATATCGCCGAATACATAGCACTTGAAAATGTCAT
GGCGGCAAAGCAGTTAGTACAAACGATATTCTCTAAAGTTGAACGCCTAGAAACTTTCCCTGAATCCGGTCGCATTCCTC
CAGAGTTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTTTATAAACAGGACAGTGACAAAGTC
TATATTTTGTTTGTTATGCGCGCTGAGAGAGATTTGCGCAAGTTCCTATTGAGTAAGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9677.22 Da
• Isoelectric Point: 7.3179

>AT33389 WP_105902158.1 NZ_AP021869:576439-576696 [Vibrio gangliei]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLVILEGIARGERALTEGKVVSHDEAKNKM
SKWLK

Nucleotide

• Length: 258 bp

>AT33389 NZ_AP021869:576439-576696 [Vibrio gangliei]
ATGAAAGTAGAACTCGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCAGATCTCCACGACACGAAAGAACCAGT
ATTAATTACTGAGCATGGTAAGCCATCTGCGTATTTAGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGTTA
TTTTGGAGGGGATTGCGCGAGGTGAGCGAGCACTAACTGAAGGTAAAGTGGTAAGTCATGATGAAGCCAAGAACAAAATG
TCAAAATGGCTGAAATAA