Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 272652..274198 Replicon chromosome
Accession NZ_AP021869
Organism Vibrio gangliei strain DSM 104291

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag Vgang_RS01260 Protein ID WP_105902589.1
Coordinates 272652..273953 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Vgang_RS01265 Protein ID WP_105902588.1
Coordinates 273953..274198 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vgang_RS01245 268619..269437 + 819 WP_245879943.1 glycosyltransferase -
Vgang_RS01250 270119..270655 - 537 WP_105902591.1 DUF6088 family protein -
Vgang_RS01255 271208..272317 + 1110 WP_105902590.1 Fic/DOC family N-terminal domain-containing protein -
Vgang_RS01260 272652..273953 - 1302 WP_105902589.1 type II toxin-antitoxin system HipA family toxin Toxin
Vgang_RS01265 273953..274198 - 246 WP_105902588.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
Vgang_RS01270 274460..275077 - 618 WP_157946026.1 hypothetical protein -
Vgang_RS01275 275081..276238 - 1158 WP_105902586.1 tyrosine-type recombinase/integrase -
Vgang_RS01280 276647..277282 + 636 WP_105902585.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 265416..293506 28090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48742.57 Da        Isoelectric Point: 8.4098

>T33388 WP_105902589.1 NZ_AP021869:c273953-272652 [Vibrio gangliei]
MQKLIAYMNGELVGTLEKHNNGAHTFQYDKNWITNAASRPLSLSLKLQLPIITSDAVINFFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGRDSVGAIALLPPELPYIKEPLRYEEIEDKKLESVLCAYKSDIPLGMLEEEEDFRISVAGVQEKTAL
LLFNGRWCLPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARAMGFTVPNVNIIQTDSIKALAVERFDRRW
TKDKKKLLRLPQEDICQVFGMPSSIKNESQGGPGIAQIMALLMGSSNAIEDRYNFMRFQVFQWLIGATDGHAKNFSIYIE
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLELSMGLKATKGKKNEISKILPRHFLDTAKAVNFSQDMMQEIMDEMKSALP
KAILQVSAALPEDFPKHISSSIFDNTQKMIKKI

Download         Length: 1302 bp

>T33388 NZ_AP021869:c273953-272652 [Vibrio gangliei]
ATGCAGAAACTAATCGCATACATGAATGGTGAACTTGTTGGCACTTTAGAGAAACATAATAATGGTGCTCACACGTTTCA
ATATGATAAAAACTGGATAACCAATGCAGCGAGTCGCCCATTATCATTGTCTTTAAAGCTTCAATTACCAATCATCACCT
CCGATGCAGTGATAAACTTTTTTGACAACCTTCTGCCAGATAGCCCTCAAGTCAGAGATAGAATCGTTGCAAGGTACAAG
GCGTCATCTAAACAACCATTTGATCTCCTAAAAGAAATTGGAAGAGACAGCGTTGGTGCCATCGCTTTACTTCCACCAGA
ATTGCCTTATATAAAAGAACCTCTTAGATACGAAGAAATTGAAGACAAAAAACTAGAATCTGTTCTTTGTGCATACAAAT
CTGATATTCCGCTTGGGATGCTCGAAGAAGAAGAAGACTTTCGGATCTCAGTAGCAGGAGTTCAAGAGAAAACAGCGCTA
CTACTCTTTAATGGGCGATGGTGTCTCCCCAAAGGTAACACGCCGACAACCCACATTATCAAATTGCCTATTGGGGAAAT
TCAGCAAGCTAACGCGACACTCGATCTTAAAGATAGCGTAGAAAACGAGTACCTCTGCATCGAGTTAGCTAGAGCGATGG
GATTCACCGTTCCCAACGTTAATATAATCCAAACAGACAGCATTAAAGCTTTAGCTGTGGAACGATTTGATAGGCGCTGG
ACAAAAGACAAAAAAAAATTACTACGCTTACCTCAAGAAGATATTTGCCAAGTATTTGGAATGCCATCGTCTATTAAAAA
TGAATCTCAAGGCGGCCCAGGGATAGCACAGATAATGGCGCTGTTAATGGGGTCAAGCAATGCCATAGAAGATCGCTATA
ACTTCATGAGATTTCAAGTATTTCAATGGCTCATTGGTGCCACAGATGGACATGCTAAAAACTTTTCGATCTATATTGAG
AAGGGAGGGAGCTATAGACTCACACCATTCTACGATATTTTATCAGCCTACCCACTACTGGGAGGAAAAGGGCTCAATAT
CAGAAAGCTAGAGCTGTCGATGGGATTGAAAGCAACAAAAGGCAAGAAGAATGAAATCAGTAAAATCCTGCCTCGTCACT
TTTTGGATACCGCTAAAGCAGTCAATTTTAGCCAAGATATGATGCAAGAGATCATGGATGAAATGAAAAGTGCCTTACCG
AAAGCGATATTGCAAGTAAGTGCTGCATTGCCTGAAGACTTTCCTAAGCATATCTCAAGTTCTATTTTTGATAATACTCA
GAAAATGATTAAGAAGATCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9196.53 Da        Isoelectric Point: 6.2564

>AT33388 WP_105902588.1 NZ_AP021869:c274198-273953 [Vibrio gangliei]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENTPNKTTLSTFFKIVQAMDLTLSIQEKSQAASLDENDES
W

Download         Length: 246 bp

>AT33388 NZ_AP021869:c274198-273953 [Vibrio gangliei]
ATGATATATAGTCCAAAACAATTAGCAGATATGATGCTACTGATACGTCAGAAGAATGGGTGGACACAATCAGAACTGGC
AAAAAAAGTTGGTATCAAGCAAGCGACGATCTCGAACTTCGAAAATACACCTAACAAAACAACGCTTTCGACTTTCTTTA
AGATTGTTCAGGCTATGGATCTAACATTGAGTATCCAAGAAAAATCACAGGCAGCTTCGTTAGATGAAAATGATGAGAGT
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References