33385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 4580177..4580844 Replicon chromosome
Accession NZ_AP021855
Organism Bradyrhizobium sp. TM102

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U8PF08
Locus tag GDN70_RS21875 Protein ID WP_028144859.1
Coordinates 4580434..4580844 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2U8PFU4
Locus tag GDN70_RS21870 Protein ID WP_028144858.1
Coordinates 4580177..4580434 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDN70_RS21845 4575584..4576024 + 441 WP_018323001.1 response regulator -
GDN70_RS21850 4576021..4577124 + 1104 WP_028144854.1 response regulator -
GDN70_RS21855 4577185..4577865 + 681 WP_028144855.1 leucyl/phenylalanyl-tRNA--protein transferase -
GDN70_RS21860 4577906..4578937 - 1032 WP_173015849.1 DUF2155 domain-containing protein -
GDN70_RS21865 4579144..4580089 + 946 Protein_4250 alpha/beta hydrolase -
GDN70_RS21870 4580177..4580434 + 258 WP_028144858.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GDN70_RS21875 4580434..4580844 + 411 WP_028144859.1 type II toxin-antitoxin system VapC family toxin Toxin
GDN70_RS21880 4580882..4581880 + 999 WP_152103024.1 Na+-dependent transporter -
GDN70_RS21885 4581877..4582815 - 939 WP_152103025.1 GlxA family transcriptional regulator -
GDN70_RS21890 4582911..4583597 + 687 WP_028144862.1 DJ-1/PfpI family protein -
GDN70_RS21895 4584099..4584506 - 408 WP_028144863.1 NADH:ubiquinone oxidoreductase subunit NDUFA12 -
GDN70_RS21900 4584750..4585415 + 666 WP_152103026.1 BA14K family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15059.18 Da        Isoelectric Point: 5.1957

>T33385 WP_028144859.1 NZ_AP021855:4580434-4580844 [Bradyrhizobium sp. TM102]
MFLLDTVTLSELRRTRRNPSVVAWMERQRTADLFLSVVSIGEIERGIERQRAADPSFADALATWLDRVLALYGTQVLPFD
LQTARRWGALSAALGNDSADLMIAATALEHGLTVVTRNVSDFEPTGVRVVNPFEGK

Download         Length: 411 bp

>T33385 NZ_AP021855:4580434-4580844 [Bradyrhizobium sp. TM102]
ATGTTTCTGCTCGACACCGTCACGCTGTCCGAGCTGCGTCGGACCAGACGCAACCCGTCGGTGGTCGCCTGGATGGAGCG
GCAGCGAACGGCAGATCTTTTCCTCAGCGTCGTCAGCATCGGCGAAATCGAACGCGGAATCGAACGTCAGCGCGCTGCAG
ATCCGAGCTTTGCCGATGCGCTCGCCACCTGGCTGGATCGCGTTCTCGCTCTCTACGGCACACAGGTCTTGCCGTTTGAC
CTCCAGACCGCGCGTCGCTGGGGAGCTCTCAGCGCCGCGCTCGGCAATGACAGCGCAGATCTCATGATTGCCGCCACCGC
GCTCGAGCATGGACTTACTGTCGTGACGCGCAATGTCTCGGACTTTGAGCCTACGGGAGTTCGCGTCGTAAATCCATTTG
AAGGCAAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9619.96 Da        Isoelectric Point: 8.9339

>AT33385 WP_028144858.1 NZ_AP021855:4580177-4580434 [Bradyrhizobium sp. TM102]
MTKRVWSVQDAKNRFSEVVHAAQRAPQTVTRHGKPAVVILNAAEFERLQELQRARAPSLTDLLLEMPQDDGEFPRARVAD
RDIGL

Download         Length: 258 bp

>AT33385 NZ_AP021855:4580177-4580434 [Bradyrhizobium sp. TM102]
ATGACCAAGCGAGTCTGGTCGGTGCAGGATGCAAAAAACCGCTTCAGCGAGGTGGTTCATGCGGCGCAGCGCGCACCGCA
AACGGTGACACGGCATGGCAAACCCGCTGTGGTGATCTTGAATGCCGCAGAGTTTGAACGCTTGCAGGAGCTGCAACGCG
CTCGGGCGCCCTCTCTGACCGATCTGCTTCTTGAAATGCCGCAAGACGACGGGGAATTTCCGCGCGCGCGTGTCGCGGAT
CGTGACATCGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U8PF08

Antitoxin

Source ID Structure
AlphaFold DB A0A2U8PFU4

References