33383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 5739383..5740050 Replicon chromosome
Accession NZ_AP021854
Organism Bradyrhizobium sp. SG09

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U8PF08
Locus tag GDN72_RS27135 Protein ID WP_028144859.1
Coordinates 5739383..5739793 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2U8PFU4
Locus tag GDN72_RS27140 Protein ID WP_028144858.1
Coordinates 5739793..5740050 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDN72_RS27110 5734812..5735477 - 666 WP_028144864.1 BA14K family protein -
GDN72_RS27115 5735721..5736128 + 408 WP_028144863.1 NADH:ubiquinone oxidoreductase subunit NDUFA12 -
GDN72_RS27120 5736630..5737316 - 687 WP_028144862.1 DJ-1/PfpI family protein -
GDN72_RS27125 5737412..5738350 + 939 WP_028144861.1 GlxA family transcriptional regulator -
GDN72_RS27130 5738347..5739345 - 999 WP_028144860.1 hypothetical protein -
GDN72_RS27135 5739383..5739793 - 411 WP_028144859.1 type II toxin-antitoxin system VapC family toxin Toxin
GDN72_RS27140 5739793..5740050 - 258 WP_028144858.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GDN72_RS27145 5740138..5741085 - 948 WP_028144857.1 alpha/beta hydrolase -
GDN72_RS27150 5741292..5742326 + 1035 WP_028144856.1 DUF2155 domain-containing protein -
GDN72_RS27155 5742367..5743047 - 681 WP_028144855.1 leucyl/phenylalanyl-tRNA--protein transferase -
GDN72_RS27160 5743111..5744214 - 1104 WP_028144854.1 response regulator -
GDN72_RS27165 5744211..5744651 - 441 WP_018323001.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15059.18 Da        Isoelectric Point: 5.1957

>T33383 WP_028144859.1 NZ_AP021854:c5739793-5739383 [Bradyrhizobium sp. SG09]
MFLLDTVTLSELRRTRRNPSVVAWMERQRTADLFLSVVSIGEIERGIERQRAADPSFADALATWLDRVLALYGTQVLPFD
LQTARRWGALSAALGNDSADLMIAATALEHGLTVVTRNVSDFEPTGVRVVNPFEGK

Download         Length: 411 bp

>T33383 NZ_AP021854:c5739793-5739383 [Bradyrhizobium sp. SG09]
ATGTTTCTGCTCGACACCGTCACGCTGTCCGAGCTGCGTCGGACCAGACGCAACCCGTCGGTGGTCGCCTGGATGGAGCG
GCAGCGAACGGCAGATCTTTTCCTCAGCGTCGTCAGCATCGGCGAAATCGAACGCGGAATCGAACGTCAACGCGCTGCAG
ATCCGAGCTTTGCCGATGCGCTCGCCACCTGGCTGGATCGCGTTCTCGCTCTCTACGGCACACAGGTCTTGCCGTTTGAC
CTCCAGACCGCGCGTCGCTGGGGAGCTCTCAGCGCCGCGCTCGGCAATGACAGCGCAGATCTCATGATTGCCGCCACCGC
GCTCGAGCATGGACTTACTGTCGTGACGCGCAATGTCTCGGACTTTGAGCCTACGGGAGTTCGCGTCGTAAATCCATTTG
AAGGCAAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9619.96 Da        Isoelectric Point: 8.9339

>AT33383 WP_028144858.1 NZ_AP021854:c5740050-5739793 [Bradyrhizobium sp. SG09]
MTKRVWSVQDAKNRFSEVVHAAQRAPQTVTRHGKPAVVILNAAEFERLQELQRARAPSLTDLLLEMPQDDGEFPRARVAD
RDIGL

Download         Length: 258 bp

>AT33383 NZ_AP021854:c5740050-5739793 [Bradyrhizobium sp. SG09]
ATGACCAAGCGAGTCTGGTCGGTGCAGGATGCAAAAAACCGCTTCAGCGAGGTGGTCCATGCGGCGCAGCGCGCACCGCA
AACGGTGACACGGCATGGCAAACCCGCTGTGGTGATCTTGAATGCCGCAGAGTTTGAACGCTTGCAGGAGCTGCAACGCG
CTCGGGCGCCCTCTCTGACCGATCTGCTTCTTGAAATGCCGCAAGACGACGGGGAATTTCCGCGCGCGCGTGTCGCGGAT
CGTGACATCGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U8PF08

Antitoxin

Source ID Structure
AlphaFold DB A0A2U8PFU4

References