Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 5739383..5740050 Replicon chromosome
Accession NZ_AP021854
Organism Bradyrhizobium sp. SG09

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U8PF08
Locus tag GDN72_RS27135 Protein ID WP_028144859.1
Coordinates 5739383..5739793 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2U8PFU4
Locus tag GDN72_RS27140 Protein ID WP_028144858.1
Coordinates 5739793..5740050 (-) Length 86 a.a.

Genomic Context

GDN72_RS27115GDN72_RS27125GDN72_RS27150GDN72_RS27110GDN72_RS27120GDN72_RS27130GDN72_RS27135GDN72_RS27140GDN72_RS27145GDN72_RS27155GDN72_RS27160GDN72_RS27165
Location: 5735721..5736128 (408 bp)
Type: Others
Protein ID: WP_028144863.1
Location: 5737412..5738350 (939 bp)
Type: Others
Protein ID: WP_028144861.1
Location: 5741292..5742326 (1035 bp)
Type: Others
Protein ID: WP_028144856.1
Location: 5734812..5735477 (666 bp)
Type: Others
Protein ID: WP_028144864.1
Location: 5736630..5737316 (687 bp)
Type: Others
Protein ID: WP_028144862.1
Location: 5738347..5739345 (999 bp)
Type: Others
Protein ID: WP_028144860.1
Location: 5739383..5739793 (411 bp)
Type: Toxin
Protein ID: WP_028144859.1
Location: 5739793..5740050 (258 bp)
Type: Antitoxin
Protein ID: WP_028144858.1
Location: 5740138..5741085 (948 bp)
Type: Others
Protein ID: WP_028144857.1
Location: 5742367..5743047 (681 bp)
Type: Others
Protein ID: WP_028144855.1
Location: 5743111..5744214 (1104 bp)
Type: Others
Protein ID: WP_028144854.1
Location: 5744211..5744651 (441 bp)
Type: Others
Protein ID: WP_018323001.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GDN72_RS271105734812..5735477-666WP_028144864.1BA14K family protein-
GDN72_RS271155735721..5736128+408WP_028144863.1NADH:ubiquinone oxidoreductase subunit NDUFA12-
GDN72_RS271205736630..5737316-687WP_028144862.1DJ-1/PfpI family protein-
GDN72_RS271255737412..5738350+939WP_028144861.1GlxA family transcriptional regulator-
GDN72_RS271305738347..5739345-999WP_028144860.1hypothetical protein-
GDN72_RS271355739383..5739793-411WP_028144859.1type II toxin-antitoxin system VapC family toxinToxin
GDN72_RS271405739793..5740050-258WP_028144858.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GDN72_RS271455740138..5741085-948WP_028144857.1alpha/beta hydrolase-
GDN72_RS271505741292..5742326+1035WP_028144856.1DUF2155 domain-containing protein-
GDN72_RS271555742367..5743047-681WP_028144855.1leucyl/phenylalanyl-tRNA--protein transferase-
GDN72_RS271605743111..5744214-1104WP_028144854.1response regulator-
GDN72_RS271655744211..5744651-441WP_018323001.1response regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15059.18 Da        Isoelectric Point: 5.1957

>T33383 WP_028144859.1 NZ_AP021854:c5739793-5739383 [Bradyrhizobium sp. SG09]
MFLLDTVTLSELRRTRRNPSVVAWMERQRTADLFLSVVSIGEIERGIERQRAADPSFADALATWLDRVLALYGTQVLPFD
LQTARRWGALSAALGNDSADLMIAATALEHGLTVVTRNVSDFEPTGVRVVNPFEGK

Download         Length: 411 bp

>T33383 NZ_AP021854:c5739793-5739383 [Bradyrhizobium sp. SG09]
ATGTTTCTGCTCGACACCGTCACGCTGTCCGAGCTGCGTCGGACCAGACGCAACCCGTCGGTGGTCGCCTGGATGGAGCG
GCAGCGAACGGCAGATCTTTTCCTCAGCGTCGTCAGCATCGGCGAAATCGAACGCGGAATCGAACGTCAACGCGCTGCAG
ATCCGAGCTTTGCCGATGCGCTCGCCACCTGGCTGGATCGCGTTCTCGCTCTCTACGGCACACAGGTCTTGCCGTTTGAC
CTCCAGACCGCGCGTCGCTGGGGAGCTCTCAGCGCCGCGCTCGGCAATGACAGCGCAGATCTCATGATTGCCGCCACCGC
GCTCGAGCATGGACTTACTGTCGTGACGCGCAATGTCTCGGACTTTGAGCCTACGGGAGTTCGCGTCGTAAATCCATTTG
AAGGCAAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9619.96 Da        Isoelectric Point: 8.9339

>AT33383 WP_028144858.1 NZ_AP021854:c5740050-5739793 [Bradyrhizobium sp. SG09]
MTKRVWSVQDAKNRFSEVVHAAQRAPQTVTRHGKPAVVILNAAEFERLQELQRARAPSLTDLLLEMPQDDGEFPRARVAD
RDIGL

Download         Length: 258 bp

>AT33383 NZ_AP021854:c5740050-5739793 [Bradyrhizobium sp. SG09]
ATGACCAAGCGAGTCTGGTCGGTGCAGGATGCAAAAAACCGCTTCAGCGAGGTGGTCCATGCGGCGCAGCGCGCACCGCA
AACGGTGACACGGCATGGCAAACCCGCTGTGGTGATCTTGAATGCCGCAGAGTTTGAACGCTTGCAGGAGCTGCAACGCG
CTCGGGCGCCCTCTCTGACCGATCTGCTTCTTGAAATGCCGCAAGACGACGGGGAATTTCCGCGCGCGCGTGTCGCGGAT
CGTGACATCGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2U8PF08

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2U8PFU4

References