Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1291927..1292585 Replicon chromosome
Accession NZ_AP021854
Organism Bradyrhizobium sp. SG09

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U8P577
Locus tag GDN72_RS06080 Protein ID WP_028139223.1
Coordinates 1291927..1292331 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2M6UP33
Locus tag GDN72_RS06085 Protein ID WP_028139222.1
Coordinates 1292331..1292585 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDN72_RS06065 1289254..1289976 - 723 WP_028139226.1 ABC transporter ATP-binding protein -
GDN72_RS06070 1290032..1290676 + 645 WP_028139225.1 arylesterase -
GDN72_RS06075 1290851..1291387 + 537 WP_028139224.1 RNA 2',3'-cyclic phosphodiesterase -
GDN72_RS06080 1291927..1292331 - 405 WP_028139223.1 type II toxin-antitoxin system VapC family toxin Toxin
GDN72_RS06085 1292331..1292585 - 255 WP_028139222.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GDN72_RS06090 1292769..1293953 + 1185 WP_028139221.1 cell division protein ZapE -
GDN72_RS06095 1294215..1295183 + 969 WP_008145224.1 malate dehydrogenase -
GDN72_RS06100 1295390..1296586 + 1197 WP_028139220.1 ADP-forming succinate--CoA ligase subunit beta -
GDN72_RS06105 1296591..1297070 + 480 WP_028139219.1 DUF1579 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14613.69 Da        Isoelectric Point: 4.5209

>T33381 WP_028139223.1 NZ_AP021854:c1292331-1291927 [Bradyrhizobium sp. SG09]
MVIDTSAIVAIALDEDDAADMERLIVDDPIRLISAATVLEATMVIETRLGDAGGREFDLWLVKIGAEIVAVDAVQADAAR
RAWRRFGKGRHAASLNYGDCFSYALAMTRGEPLLFKGEDFAKTDINRSSVTPLR

Download         Length: 405 bp

>T33381 NZ_AP021854:c1292331-1291927 [Bradyrhizobium sp. SG09]
ATGGTGATCGACACATCCGCGATCGTGGCAATCGCGCTCGACGAAGACGATGCCGCGGATATGGAGCGACTGATCGTGGA
CGATCCGATCCGCCTGATTTCCGCGGCGACGGTGCTTGAAGCGACGATGGTGATCGAGACGCGGCTGGGCGATGCGGGCG
GGCGCGAGTTCGATCTCTGGCTCGTCAAGATCGGCGCTGAGATCGTCGCGGTCGATGCCGTGCAAGCCGACGCGGCCCGG
CGCGCCTGGCGGCGTTTCGGAAAAGGGCGTCACGCCGCGTCGCTCAATTACGGTGACTGCTTTTCTTATGCGCTGGCCAT
GACCCGTGGCGAACCACTGCTGTTCAAAGGCGAGGACTTTGCGAAGACCGACATCAACCGGTCGAGCGTGACGCCGCTGC
GATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9766.05 Da        Isoelectric Point: 5.7529

>AT33381 WP_028139222.1 NZ_AP021854:c1292585-1292331 [Bradyrhizobium sp. SG09]
MALSIKDPETEQLARSLAQLTGENITTATKRAIEERLRRLNAQTHKDALLEDLAEIRRRWSEMRVLDDRKPEEILGYDDH
GLPR

Download         Length: 255 bp

>AT33381 NZ_AP021854:c1292585-1292331 [Bradyrhizobium sp. SG09]
ATGGCGCTGAGCATCAAGGACCCCGAAACCGAGCAACTGGCCCGGAGTCTGGCACAATTGACGGGGGAGAACATCACGAC
TGCGACCAAGCGCGCGATCGAGGAGCGATTGCGCCGGCTCAACGCTCAAACACACAAGGACGCGCTGCTTGAAGACCTTG
CCGAGATCAGACGGCGCTGGAGCGAGATGCGCGTCCTGGACGACCGCAAGCCTGAAGAAATCCTCGGATACGACGATCAT
GGATTGCCCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U8P577

Antitoxin

Source ID Structure
AlphaFold DB A0A2M6UP33

References