Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2882170..2882802 Replicon chromosome
Accession NZ_AP021853
Organism Sporolactobacillus terrae strain 70-3

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U1QR24
Locus tag St703_RS13880 Protein ID WP_010025898.1
Coordinates 2882170..2882520 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U1QQW7
Locus tag St703_RS13885 Protein ID WP_010025899.1
Coordinates 2882524..2882802 (-) Length 93 a.a.

Genomic Context

St703_RS13860St703_RS13865St703_RS13870St703_RS13875St703_RS13880St703_RS13885St703_RS13890St703_RS13895St703_RS13900St703_RS13905
Location: 2879057..2879845 (789 bp)
Type: Others
Protein ID: WP_037582118.1
Location: 2879817..2880296 (480 bp)
Type: Others
Protein ID: WP_028984087.1
Location: 2880289..2880627 (339 bp)
Type: Others
Protein ID: WP_028975631.1
Location: 2880691..2881689 (999 bp)
Type: Others
Protein ID: WP_028984086.1
Location: 2882170..2882520 (351 bp)
Type: Toxin
Protein ID: WP_010025898.1
Location: 2882524..2882802 (279 bp)
Type: Antitoxin
Protein ID: WP_010025899.1
Location: 2882963..2884153 (1191 bp)
Type: Others
Protein ID: WP_152080754.1
Location: 2884391..2885401 (1011 bp)
Type: Others
Protein ID: WP_128167161.1
Location: 2885449..2886963 (1515 bp)
Type: Others
Protein ID: WP_028984083.1
Location: 2887019..2887381 (363 bp)
Type: Others
Protein ID: WP_028984082.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
St703_RS138602879057..2879845-789WP_037582118.1RNA polymerase sigma factor SigB-
St703_RS138652879817..2880296-480WP_028984087.1anti-sigma B factor RsbW-
St703_RS138702880289..2880627-339WP_028975631.1STAS domain-containing protein-
St703_RS138752880691..2881689-999WP_028984086.1SpoIIE family protein phosphatase-
St703_RS138802882170..2882520-351WP_010025898.1type II toxin-antitoxin system PemK/MazF family toxinToxin
St703_RS138852882524..2882802-279WP_010025899.1antitoxinAntitoxin
St703_RS138902882963..2884153-1191WP_152080754.1alanine racemase-
St703_RS138952884391..2885401-1011WP_128167161.1outer membrane lipoprotein carrier protein LolA-
St703_RS139002885449..2886963-1515WP_028984083.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
St703_RS139052887019..2887381-363WP_028984082.1holo-ACP synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.96 Da        Isoelectric Point: 6.4684

>T33380 WP_010025898.1 NZ_AP021853:c2882520-2882170 [Sporolactobacillus terrae]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHVEIDAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMGQVNKAIQISLSLIDF

Download         Length: 351 bp

>T33380 NZ_AP021853:c2882520-2882170 [Sporolactobacillus terrae]
GTGATTGTTAAACGCGGCGACGTCTACTTTGCAGATCTCTCTCCGGTTGTCGGATCGGAACAGGGCGGGGTCCGCCCCGT
TCTGATCATCCAGAATGACATTGGCAATCGCTTTAGCCCAACGGTTGTTGTGGCGGCTATCACCGCCCAAATTCAAAAAG
CCAAATTGCCGACTCATGTGGAGATCGATGCAAAACGGTACGGATTCGATCGCGACTCGGTTATCTTGCTTGAGCAGATC
AGAACCATTGACAAGCAGCGACTGACGGATAAAATCACGCATCTAGACGAAGAAATGATGGGCCAAGTAAATAAAGCCAT
TCAGATCAGTCTGAGTTTGATTGACTTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10759.43 Da        Isoelectric Point: 6.4768

>AT33380 WP_010025899.1 NZ_AP021853:c2882802-2882524 [Sporolactobacillus terrae]
MSESKIKEIMLSLPQHLLNEIDGMASRDKMNRSEFLHRAIRLYLRERNRGYVREIMRQGYMEMAKINLNLASEAFLAEEE
AEITLERSVSGV

Download         Length: 279 bp

>AT33380 NZ_AP021853:c2882802-2882524 [Sporolactobacillus terrae]
ATGTCGGAATCGAAGATAAAAGAAATCATGCTGAGTTTGCCGCAACATTTATTGAACGAGATTGATGGAATGGCAAGTCG
AGACAAGATGAATCGCAGCGAATTTCTCCATCGCGCCATCAGGTTGTATCTGCGTGAGCGTAATAGGGGCTATGTCCGTG
AAATTATGCGTCAGGGCTACATGGAAATGGCTAAAATTAATCTAAATCTTGCTTCTGAAGCTTTTCTTGCTGAAGAGGAG
GCAGAGATCACACTGGAACGCTCCGTCAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0U1QR24

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U1QQW7

References