Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2882170..2882802 Replicon chromosome
Accession NZ_AP021853
Organism Sporolactobacillus terrae strain 70-3

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U1QR24
Locus tag St703_RS13880 Protein ID WP_010025898.1
Coordinates 2882170..2882520 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U1QQW7
Locus tag St703_RS13885 Protein ID WP_010025899.1
Coordinates 2882524..2882802 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
St703_RS13860 2879057..2879845 - 789 WP_037582118.1 RNA polymerase sigma factor SigB -
St703_RS13865 2879817..2880296 - 480 WP_028984087.1 anti-sigma B factor RsbW -
St703_RS13870 2880289..2880627 - 339 WP_028975631.1 STAS domain-containing protein -
St703_RS13875 2880691..2881689 - 999 WP_028984086.1 SpoIIE family protein phosphatase -
St703_RS13880 2882170..2882520 - 351 WP_010025898.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
St703_RS13885 2882524..2882802 - 279 WP_010025899.1 antitoxin Antitoxin
St703_RS13890 2882963..2884153 - 1191 WP_152080754.1 alanine racemase -
St703_RS13895 2884391..2885401 - 1011 WP_128167161.1 outer membrane lipoprotein carrier protein LolA -
St703_RS13900 2885449..2886963 - 1515 WP_028984083.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
St703_RS13905 2887019..2887381 - 363 WP_028984082.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.96 Da        Isoelectric Point: 6.4684

>T33380 WP_010025898.1 NZ_AP021853:c2882520-2882170 [Sporolactobacillus terrae]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHVEIDAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMGQVNKAIQISLSLIDF

Download         Length: 351 bp

>T33380 NZ_AP021853:c2882520-2882170 [Sporolactobacillus terrae]
GTGATTGTTAAACGCGGCGACGTCTACTTTGCAGATCTCTCTCCGGTTGTCGGATCGGAACAGGGCGGGGTCCGCCCCGT
TCTGATCATCCAGAATGACATTGGCAATCGCTTTAGCCCAACGGTTGTTGTGGCGGCTATCACCGCCCAAATTCAAAAAG
CCAAATTGCCGACTCATGTGGAGATCGATGCAAAACGGTACGGATTCGATCGCGACTCGGTTATCTTGCTTGAGCAGATC
AGAACCATTGACAAGCAGCGACTGACGGATAAAATCACGCATCTAGACGAAGAAATGATGGGCCAAGTAAATAAAGCCAT
TCAGATCAGTCTGAGTTTGATTGACTTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10759.43 Da        Isoelectric Point: 6.4768

>AT33380 WP_010025899.1 NZ_AP021853:c2882802-2882524 [Sporolactobacillus terrae]
MSESKIKEIMLSLPQHLLNEIDGMASRDKMNRSEFLHRAIRLYLRERNRGYVREIMRQGYMEMAKINLNLASEAFLAEEE
AEITLERSVSGV

Download         Length: 279 bp

>AT33380 NZ_AP021853:c2882802-2882524 [Sporolactobacillus terrae]
ATGTCGGAATCGAAGATAAAAGAAATCATGCTGAGTTTGCCGCAACATTTATTGAACGAGATTGATGGAATGGCAAGTCG
AGACAAGATGAATCGCAGCGAATTTCTCCATCGCGCCATCAGGTTGTATCTGCGTGAGCGTAATAGGGGCTATGTCCGTG
AAATTATGCGTCAGGGCTACATGGAAATGGCTAAAATTAATCTAAATCTTGCTTCTGAAGCTTTTCTTGCTGAAGAGGAG
GCAGAGATCACACTGGAACGCTCCGTCAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1QR24

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1QQW7

References