Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1124946..1125481 Replicon chromosome
Accession NZ_AP021848
Organism Staphylococcus lugdunensis strain JICS135

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag MRSL_RS05260 Protein ID WP_002445368.1
Coordinates 1125158..1125481 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag MRSL_RS05255 Protein ID WP_001058489.1
Coordinates 1124946..1125155 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRSL_RS05220 1120202..1120486 + 285 WP_002461410.1 co-chaperone GroES -
MRSL_RS05225 1120546..1122168 + 1623 WP_002461409.1 chaperonin GroEL -
MRSL_RS05230 1122237..1123409 - 1173 WP_002492309.1 site-specific integrase -
MRSL_RS05235 1123423..1124097 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
MRSL_RS05240 1124270..1124488 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
MRSL_RS05245 1124493..1124810 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
MRSL_RS05250 1124807..1124953 + 147 WP_002445365.1 hypothetical protein -
MRSL_RS05255 1124946..1125155 + 210 WP_001058489.1 hypothetical protein Antitoxin
MRSL_RS05260 1125158..1125481 + 324 WP_002445368.1 DUF1474 family protein Toxin
MRSL_RS05265 1125545..1126414 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
MRSL_RS05270 1126428..1128137 + 1710 WP_002445371.1 DUF927 domain-containing protein -
MRSL_RS05275 1128485..1128850 + 366 WP_002445372.1 hypothetical protein -
MRSL_RS05280 1128864..1129505 + 642 WP_002492310.1 pathogenicity island protein -
MRSL_RS05285 1129793..1130137 + 345 WP_094449183.1 pathogenicity island protein -
MRSL_RS05290 1130151..1130384 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 1120202..1133374 13172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T33378 WP_002445368.1 NZ_AP021848:1125158-1125481 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T33378 NZ_AP021848:1125158-1125481 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT33378 WP_001058489.1 NZ_AP021848:1124946-1125155 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT33378 NZ_AP021848:1124946-1125155 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References