Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1073392..1073909 Replicon chromosome
Accession NZ_AP021848
Organism Staphylococcus lugdunensis strain JICS135

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag MRSL_RS05005 Protein ID WP_002461192.1
Coordinates 1073559..1073909 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag MRSL_RS05000 Protein ID WP_002461193.1
Coordinates 1073392..1073562 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRSL_RS04975 1069217..1069699 + 483 WP_002492078.1 PH domain-containing protein -
MRSL_RS04980 1069692..1071206 + 1515 WP_002492082.1 PH domain-containing protein -
MRSL_RS04985 1071193..1071705 + 513 WP_002461197.1 PH domain-containing protein -
MRSL_RS04990 1071717..1072109 + 393 WP_002461196.1 holo-ACP synthase -
MRSL_RS04995 1072157..1073305 + 1149 WP_002492086.1 alanine racemase -
MRSL_RS05000 1073392..1073562 + 171 WP_002461193.1 hypothetical protein Antitoxin
MRSL_RS05005 1073559..1073909 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MRSL_RS05010 1074342..1075343 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
MRSL_RS05015 1075434..1075760 + 327 WP_002461190.1 anti-sigma factor antagonist -
MRSL_RS05020 1075762..1076241 + 480 WP_037540680.1 anti-sigma B factor RsbW -
MRSL_RS05025 1076216..1076986 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T33377 WP_002461192.1 NZ_AP021848:1073559-1073909 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T33377 NZ_AP021848:1073559-1073909 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT33377 WP_002461193.1 NZ_AP021848:1073392-1073562 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT33377 NZ_AP021848:1073392-1073562 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References