Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1061994..1062512 Replicon chromosome
Accession NZ_AP021848
Organism Staphylococcus lugdunensis strain JICS135

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag MRSL_RS04945 Protein ID WP_002492077.1
Coordinates 1062300..1062512 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag MRSL_RS04940 Protein ID WP_002492098.1
Coordinates 1061994..1062287 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRSL_RS04915 1057594..1058232 + 639 WP_002492090.1 thiamine phosphate synthase -
MRSL_RS04920 1058322..1059197 + 876 WP_002461212.1 membrane protein insertase YidC -
MRSL_RS04925 1059298..1059471 - 174 WP_172412323.1 hypothetical protein -
MRSL_RS04930 1059581..1060222 - 642 WP_002492092.1 HD domain-containing protein -
MRSL_RS04935 1060344..1061828 - 1485 WP_002478972.1 cardiolipin synthase -
MRSL_RS04940 1061994..1062287 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
MRSL_RS04945 1062300..1062512 + 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
MRSL_RS04950 1062603..1062740 + 138 WP_002461206.1 hypothetical protein -
MRSL_RS04955 1063154..1064344 - 1191 WP_002461205.1 rod shape-determining protein RodA -
MRSL_RS04960 1064700..1065770 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
MRSL_RS04965 1065788..1067146 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T33376 WP_002492077.1 NZ_AP021848:1062300-1062512 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T33376 NZ_AP021848:1062300-1062512 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT33376 WP_002492098.1 NZ_AP021848:1061994-1062287 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT33376 NZ_AP021848:1061994-1062287 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References