Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1983157..1983793 Replicon chromosome
Accession NZ_AP020335
Organism Hydrogenovibrio marinus strain MH-110

Toxin (Protein)


Gene name vapC Uniprot ID A0A066ZSQ7
Locus tag HVMH_RS09460 Protein ID WP_029912863.1
Coordinates 1983157..1983558 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A067A1N0
Locus tag HVMH_RS09465 Protein ID WP_029912860.1
Coordinates 1983551..1983793 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVMH_RS09425 1978714..1979742 + 1029 WP_029912877.1 lipoyl synthase -
HVMH_RS09430 1979742..1980602 + 861 WP_029912874.1 Hsp33 family molecular chaperone HslO -
HVMH_RS09435 1980716..1981255 + 540 WP_029912871.1 DUF2062 domain-containing protein -
HVMH_RS09440 1981348..1982343 + 996 WP_051623142.1 AraC family transcriptional regulator -
HVMH_RS09450 1982629..1982850 - 222 WP_029912865.1 helix-turn-helix domain-containing protein -
HVMH_RS09455 1982871..1983041 - 171 WP_155837703.1 hypothetical protein -
HVMH_RS09460 1983157..1983558 - 402 WP_029912863.1 type II toxin-antitoxin system VapC family toxin Toxin
HVMH_RS09465 1983551..1983793 - 243 WP_029912860.1 antitoxin Antitoxin
HVMH_RS09470 1984027..1984317 - 291 WP_029912856.1 HigA family addiction module antidote protein -
HVMH_RS09475 1984326..1984607 - 282 WP_029912854.1 type II toxin-antitoxin system RelE/ParE family toxin -
HVMH_RS09480 1984783..1985178 - 396 WP_029912851.1 hypothetical protein -
HVMH_RS09485 1985237..1986898 - 1662 WP_155837702.1 hypothetical protein -
HVMH_RS09490 1987085..1987522 + 438 WP_029912845.1 hypothetical protein -
HVMH_RS09495 1987640..1987900 + 261 WP_029912842.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HVMH_RS09500 1987900..1988214 + 315 WP_029912839.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14999.21 Da        Isoelectric Point: 7.4339

>T33370 WP_029912863.1 NZ_AP020335:c1983558-1983157 [Hydrogenovibrio marinus]
MIKYLLDTNICIYVIKRRPIEVLERFNEASGHIAISSITLAELLHGVEKSKHVAKNLKAVEDFCSRLDVINYDENAASHY
GDIRADLERKGKTIGVNDLHIAGHARSIGAILVSNNLKEFERVEGLRFQNWIG

Download         Length: 402 bp

>T33370 NZ_AP020335:c1983558-1983157 [Hydrogenovibrio marinus]
ATGATTAAGTATTTACTGGACACGAATATTTGTATTTATGTCATCAAGCGTAGACCAATCGAGGTTCTTGAAAGATTCAA
TGAGGCATCAGGACATATCGCAATATCTTCTATTACGCTTGCTGAACTGTTGCATGGTGTTGAAAAGAGTAAGCATGTTG
CCAAAAACCTGAAAGCGGTTGAAGACTTTTGCAGTCGTTTGGATGTCATAAATTATGACGAAAACGCGGCATCACATTAC
GGTGATATTCGCGCCGATTTAGAAAGAAAAGGCAAAACGATTGGTGTCAATGATTTGCACATAGCAGGTCACGCAAGAAG
TATTGGCGCTATTCTTGTGAGCAATAACCTAAAAGAATTTGAACGTGTCGAAGGTTTAAGGTTTCAAAACTGGATTGGCT
GA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9156.34 Da        Isoelectric Point: 4.7719

>AT33370 WP_029912860.1 NZ_AP020335:c1983793-1983551 [Hydrogenovibrio marinus]
MINATVFENNKTQAVRLPVAVRFPDSVKKVVVRVVGKERIISPLKNTWDSFFLNPETSVSDDFLNERAEQTEALRESFDD

Download         Length: 243 bp

>AT33370 NZ_AP020335:c1983793-1983551 [Hydrogenovibrio marinus]
TTGATTAATGCAACTGTTTTTGAAAACAACAAAACACAAGCTGTTCGCCTACCCGTTGCTGTTCGTTTTCCTGATTCAGT
AAAAAAAGTTGTTGTTCGTGTTGTGGGTAAAGAACGAATTATTAGCCCGTTAAAAAATACATGGGACAGTTTCTTTTTAA
ATCCAGAAACATCGGTTTCAGATGATTTTTTGAATGAACGTGCTGAACAAACAGAAGCTTTGAGAGAGTCGTTTGATGAT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066ZSQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A067A1N0

References