Detailed information of TA system TA033369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 1924977..1925731
• Replicon: chromosome
• Accession: NZ_AP020335
• Organism: Hydrogenovibrio marinus strain MH-110

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: HVMH_RS09170
• Protein ID: WP_029913026.1
• Coordinates: 1924977..1925480 (-)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A066ZWC3
• Locus tag: HVMH_RS09175
• Protein ID: WP_029913022.1
• Coordinates: 1925468..1925731 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVMH_RS09135	1920030..1920245	-	216	WP_029913042.1	AlpA family phage regulatory protein	-
HVMH_RS09140	1920555..1921304	-	750	WP_029913039.1	hypothetical protein	-
HVMH_RS09145	1921490..1922029	+	540	WP_029913036.1	hypothetical protein	-
HVMH_RS09150	1922122..1922823	+	702	WP_029913034.1	hypothetical protein	-
HVMH_RS11805	1922803..1923276	-	474	WP_051682481.1	site-specific integrase	-
HVMH_RS11810	1923270..1923713	-	444	WP_051682480.1	hypothetical protein	-
HVMH_RS09160	1923756..1924241	-	486	WP_029913032.1	DNA repair protein RadC	-
HVMH_RS09165	1924238..1924774	-	537	WP_029913029.1	hypothetical protein	-
HVMH_RS09170	1924977..1925480	-	504	WP_029913026.1	GNAT family N-acetyltransferase	Toxin
HVMH_RS09175	1925468..1925731	-	264	WP_029913022.1	DUF1778 domain-containing protein	Antitoxin
HVMH_RS09180	1925820..1926197	-	378	WP_029913018.1	helix-turn-helix domain-containing protein	-
HVMH_RS09185	1926319..1926813	+	495	WP_029913015.1	hypothetical protein	-
HVMH_RS09190	1926813..1927811	+	999	WP_029913013.1	WYL domain-containing protein	-
HVMH_RS09195	1927906..1928238	+	333	WP_029913011.1	hypothetical protein	-
HVMH_RS09200	1928271..1929011	+	741	WP_029913002.1	hypothetical protein	-
HVMH_RS09205	1929107..1929781	-	675	WP_029913000.1	TIGR02646 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1917458..1929011	11553

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-80)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18063.07 Da
• Isoelectric Point: 7.8455

>T33369 WP_029913026.1 NZ_AP020335:c1925480-1924977 [Hydrogenovibrio marinus]
MGTLNAPQPLTEIFDISQFDCGNELLNHWLKKRALKNQKDGGSRTFVVVSGDCVVGYYALATGSVERNLAPSTIARNAPD
PVPVMVLGRLAVDVTMQGSGIGAGMLKDVLLRVYRVAQEAGVKALLVHALSDQAKAFYLRYGFVESPMDSMTLMLPIKAI
VNIIENP

Nucleotide

• Length: 504 bp

>T33369 NZ_AP020335:c1925480-1924977 [Hydrogenovibrio marinus]
TTGGGAACATTAAACGCCCCACAGCCATTAACTGAGATATTTGATATTAGCCAATTCGATTGTGGCAATGAATTGTTGAA
TCACTGGTTAAAGAAACGGGCTTTGAAAAACCAAAAAGACGGTGGTAGTCGTACCTTTGTGGTGGTTTCAGGTGATTGTG
TCGTGGGGTATTATGCGCTGGCGACAGGAAGCGTGGAAAGAAACCTTGCGCCTTCGACTATAGCTAGAAACGCACCAGAC
CCTGTGCCTGTTATGGTGCTGGGTCGCCTGGCTGTTGATGTCACGATGCAGGGTAGTGGTATTGGTGCGGGGATGCTTAA
AGATGTGCTGCTTCGTGTATATAGAGTTGCACAAGAAGCGGGTGTAAAAGCACTGTTAGTGCATGCCTTGTCTGATCAAG
CTAAGGCTTTTTATCTGAGGTATGGTTTTGTTGAGTCGCCAATGGATTCTATGACGCTTATGCTTCCTATTAAAGCAATA
GTTAATATTATAGAAAACCCTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9749.13 Da
• Isoelectric Point: 4.7824

>AT33369 WP_029913022.1 NZ_AP020335:c1925731-1925468 [Hydrogenovibrio marinus]
MSKTASINMRVDDSQRALLTKAADALSMDRTAFILNVACKEAQDVLLDQRLFQLDEKGFQAFEAALDAPVETSRLEALLK
RPSPWEH

Nucleotide

• Length: 264 bp

>AT33369 NZ_AP020335:c1925731-1925468 [Hydrogenovibrio marinus]
ATGTCTAAAACTGCATCTATTAATATGCGAGTAGATGACTCTCAAAGAGCTTTACTGACTAAAGCCGCTGATGCCTTGAG
CATGGATAGAACGGCATTTATTTTGAATGTTGCGTGTAAAGAAGCGCAAGACGTGCTTTTGGATCAGCGGTTGTTTCAAT
TGGATGAAAAAGGGTTTCAAGCGTTTGAAGCAGCCCTTGACGCACCTGTAGAAACAAGTCGATTGGAAGCTTTATTAAAG
AGACCATCTCCTTGGGAACATTAA

Structures

Antitoxin

• AlphaFold DB: A0A066ZWC3