Detailed information of TA system TA033368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1646880..1648465
• Replicon: chromosome
• Accession: NZ_AP020335
• Organism: Hydrogenovibrio marinus strain MH-110

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HVMH_RS07880
• Protein ID: WP_081822799.1
• Coordinates: 1646880..1648172 (-)
• Length: 431 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A066ZZC0
• Locus tag: HVMH_RS07885
• Protein ID: WP_029909690.1
• Coordinates: 1648214..1648465 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVMH_RS07865	1644096..1645013	+	918	WP_029909682.1	histone deacetylase family protein	-
HVMH_RS07870	1645092..1645349	+	258	Protein_1535	DUF3175 domain-containing protein	-
HVMH_RS07875	1645385..1646863	-	1479	WP_029909685.1	type I restriction-modification system subunit M	-
HVMH_RS07880	1646880..1648172	-	1293	WP_081822799.1	type II toxin-antitoxin system HipA family toxin	Toxin
HVMH_RS07885	1648214..1648465	-	252	WP_029909690.1	helix-turn-helix domain-containing protein	Antitoxin
HVMH_RS07890	1648568..1649509	-	942	WP_029909693.1	hypothetical protein	-
HVMH_RS07895	1649478..1650947	-	1470	WP_035628849.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (1-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 431 a.a.
• Molecular weight: 48130.46 Da
• Isoelectric Point: 6.4240

>T33368 WP_081822799.1 NZ_AP020335:c1648172-1646880 [Hydrogenovibrio marinus]
MNGLLVGELWKLKNGALQFRYADEWLDSPYARSLSFSLPLSKKVYEGDVIYNFLDNLLPDNDAIRAKMQARFHTTTTQPF
DLLAAVGSDCVGAIQLSSERLANDENLHAKPLSDAEIAEILKGYASNPLGMQDEDEDFRISIAGAQEKTALLKMEGEWFL
PKGTTPTTHILKLPIGKLAYNNLDLSQSCENEWLCMQIAKAYGLPVAEADVVMFEDQKVLAVERFDRKWVNASKLVRLPQ
EDMCQAMGVAPAIKYEADGGPGIKDMMDMLRGSQNAQADREVVFKSQVLFWMLAAPDGHGKNFSLFIEQNNGFHLTPLYD
ILSAYPLIGGTGLQKQKIKMAMAVQGKKRHYNWHSILPRHFLTTAKAVGYSEKLALSHLKEMFSKTPQVIEEVKKKLPED
FPKEIAKPIFEGLAKQAEAGKRYLAAIEKE

Nucleotide

• Length: 1293 bp

>T33368 NZ_AP020335:c1648172-1646880 [Hydrogenovibrio marinus]
ATGAATGGCTTATTGGTAGGCGAGTTGTGGAAATTGAAAAATGGTGCTTTGCAGTTTCGTTATGCGGATGAGTGGTTGGA
TTCACCCTATGCGCGTTCTTTGTCTTTTTCTTTGCCCTTGTCTAAAAAGGTCTATGAAGGTGATGTGATTTATAACTTTC
TGGACAACTTGTTGCCGGATAATGATGCTATTCGTGCAAAGATGCAAGCACGTTTCCATACCACAACAACTCAGCCATTT
GATTTGTTAGCCGCAGTGGGAAGTGACTGTGTGGGGGCGATACAACTTTCAAGCGAACGCTTGGCAAATGATGAAAACCT
TCATGCGAAGCCACTTAGTGATGCTGAAATAGCGGAAATCCTTAAGGGCTATGCTTCTAATCCACTGGGTATGCAGGATG
AGGATGAAGATTTTCGTATTTCCATTGCTGGTGCTCAGGAAAAAACGGCGCTATTAAAAATGGAAGGCGAGTGGTTTTTA
CCAAAAGGCACCACACCCACAACGCATATATTGAAACTCCCAATAGGGAAGCTGGCTTATAACAACCTAGATTTGTCTCA
AAGCTGTGAAAACGAGTGGTTATGTATGCAGATTGCCAAAGCATATGGTTTACCCGTCGCTGAAGCTGATGTAGTGATGT
TTGAAGACCAAAAAGTACTGGCGGTTGAGCGTTTTGATCGTAAATGGGTAAATGCTTCTAAACTGGTGAGATTGCCTCAG
GAAGATATGTGTCAGGCCATGGGCGTTGCACCAGCGATTAAATACGAAGCTGATGGTGGCCCGGGCATTAAAGACATGAT
GGATATGCTGAGAGGTTCACAAAATGCTCAGGCTGATAGAGAAGTGGTGTTTAAGTCTCAGGTTTTGTTTTGGATGCTGG
CGGCACCGGATGGACATGGTAAGAATTTTAGTTTGTTTATAGAGCAGAATAACGGTTTTCATTTAACGCCTTTGTATGAC
ATTTTATCGGCTTATCCATTAATTGGTGGAACGGGGTTGCAAAAGCAGAAGATTAAAATGGCTATGGCAGTGCAAGGCAA
AAAGCGGCATTACAATTGGCACTCTATTTTACCGAGGCATTTTTTAACCACCGCAAAGGCGGTTGGTTACTCTGAAAAGT
TGGCACTAAGCCACTTAAAAGAGATGTTTTCCAAAACGCCTCAAGTAATAGAAGAAGTGAAGAAGAAACTGCCGGAAGAT
TTCCCTAAAGAAATTGCTAAGCCCATTTTTGAAGGGTTGGCAAAGCAGGCTGAAGCAGGCAAGCGTTATTTAGCTGCCAT
TGAGAAAGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9221.42 Da
• Isoelectric Point: 6.2900

>AT33368 WP_029909690.1 NZ_AP020335:c1648465-1648214 [Hydrogenovibrio marinus]
MRVNSAKELSVYLQDKRVSNNLSQTTVADLASMRQATVSAFESKPDSAKLETLFKLLSALDLELEVRPKGSAFDQNTSSK
LDW

Nucleotide

• Length: 252 bp

>AT33368 NZ_AP020335:c1648465-1648214 [Hydrogenovibrio marinus]
ATGAGAGTAAATTCAGCAAAAGAGTTATCGGTTTATCTTCAAGATAAACGCGTGTCCAATAACTTATCACAAACCACGGT
TGCAGATTTGGCGAGTATGCGTCAAGCAACAGTGTCTGCATTTGAGTCTAAGCCTGACTCTGCAAAATTAGAAACACTTT
TTAAGTTGTTATCCGCCTTGGATTTAGAGTTGGAGGTTCGACCAAAAGGCAGTGCTTTTGATCAAAATACCTCATCAAAA
CTTGATTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A066ZZC0