Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 20968..21595 Replicon plasmid p2-JPH1
Accession NZ_AP020328
Organism Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)


Gene name mazF Uniprot ID A0A854IFX7
Locus tag JPH1_RS27020 Protein ID WP_054585721.1
Coordinates 20968..21366 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U5MRR7
Locus tag JPH1_RS27025 Protein ID WP_054585712.1
Coordinates 21359..21595 (-) Length 79 a.a.

Genomic Context

JPH1_RS26995JPH1_RS27000JPH1_RS27005JPH1_RS27010JPH1_RS27015JPH1_RS27020JPH1_RS27025JPH1_RS27030
Location: 16554..17003 (450 bp)
Type: Others
Protein ID: WP_054585713.1
Location: 17119..17865 (747 bp)
Type: Others
Protein ID: WP_082385902.1
Location: 18156..18419 (264 bp)
Type: Others
Protein ID: WP_139315510.1
Location: 18518..19921 (1404 bp)
Type: Others
Protein ID: WP_054585723.1
Location: 20140..20718 (579 bp)
Type: Others
Protein ID: WP_054585722.1
Location: 20968..21366 (399 bp)
Type: Toxin
Protein ID: WP_054585721.1
Location: 21359..21595 (237 bp)
Type: Antitoxin
Protein ID: WP_054585712.1
Location: 21725..23209 (1485 bp)
Type: Others
Protein ID: WP_054585711.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JPH1_RS2699516554..17003+450WP_054585713.1hypothetical protein-
JPH1_RS2700017119..17865-747WP_082385902.1Crp/Fnr family transcriptional regulator-
JPH1_RS2700518156..18419-264WP_139315510.1hypothetical protein-
JPH1_RS2701018518..19921-1404WP_054585723.1DUF2156 domain-containing protein-
JPH1_RS2701520140..20718-579WP_054585722.1recombinase family protein-
JPH1_RS2702020968..21366-399WP_054585721.1type II toxin-antitoxin system PemK/MazF family toxinToxin
JPH1_RS2702521359..21595-237WP_054585712.1antitoxinAntitoxin
JPH1_RS2703021725..23209-1485WP_054585711.1NAD(P)/FAD-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..3920639206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14306.44 Da        Isoelectric Point: 6.9865

>T33367 WP_054585721.1 NZ_AP020328:c21366-20968 [Mycobacterium avium subsp. hominissuis]
MPEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPAVSPAEGVDTDSVAVCRSI
RAVARTRLVERLGTIRPGTMREIEDVLTLILGIYTAQDRGEPTLRRPFLSDT

Download         Length: 399 bp

>T33367 NZ_AP020328:c21366-20968 [Mycobacterium avium subsp. hominissuis]
TTGCCTGAGCCGCGACGGGGCGACCTCTGGCTGGTCAGCCTTGGCGCCGCTCGCGCCGGTGAGCCCGGCAAACATCGCCC
CGCCGTAGTCGTCTCCGTCGATGAGCTACTCACCGGCATCGACGACGAACTCGTCGTGGTCGTGCCAGTGTCAAGCTCCC
GCTCGCGCACCCCGCTCCGGCCAGCCGTCTCGCCCGCTGAAGGTGTGGATACTGATAGCGTTGCCGTCTGCCGCAGCATC
CGCGCAGTCGCCCGCACCCGCCTAGTGGAACGACTCGGCACCATCAGGCCCGGCACGATGCGCGAAATCGAAGATGTCCT
GACCCTCATTCTCGGCATCTACACGGCACAAGACCGTGGCGAGCCGACATTACGGCGCCCCTTCCTGAGTGACACATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8636.54 Da        Isoelectric Point: 4.8047

>AT33367 WP_054585712.1 NZ_AP020328:c21595-21359 [Mycobacterium avium subsp. hominissuis]
MSTSTTTIRVPIQTRDRLAAQARERGISISAFLTELASQAERQAIFRVERDAIHAEAAAHAVREEDRDWEDTVGDGLA

Download         Length: 237 bp

>AT33367 NZ_AP020328:c21595-21359 [Mycobacterium avium subsp. hominissuis]
ATGTCTACATCCACGACGACGATCAGGGTTCCCATCCAGACGCGTGACCGCCTAGCCGCCCAAGCCCGTGAACGAGGAAT
CTCGATCTCCGCTTTCCTCACCGAACTGGCCTCCCAGGCCGAGCGCCAGGCGATCTTCCGCGTCGAACGCGACGCCATAC
ACGCCGAAGCGGCTGCCCACGCCGTGCGCGAGGAGGACCGCGATTGGGAGGACACCGTAGGCGATGGCCTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A854IFX7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U5MRR7

References