Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2643244..2644242 Replicon chromosome
Accession NZ_AP020326
Organism Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag JPH1_RS12475 Protein ID WP_003876749.1
Coordinates 2643664..2644242 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID X7VRE0
Locus tag JPH1_RS12470 Protein ID WP_033710872.1
Coordinates 2643244..2643633 (+) Length 130 a.a.

Genomic Context

JPH1_RS12455JPH1_RS12460JPH1_RS12465JPH1_RS12470JPH1_RS12475JPH1_RS12485JPH1_RS12490JPH1_RS12500JPH1_RS12450JPH1_RS12480JPH1_RS12495
Location: 2639139..2640656 (1518 bp)
Type: Others
Protein ID: WP_011724808.1
Location: 2640675..2642672 (1998 bp)
Type: Others
Protein ID: WP_033710859.1
Location: 2642669..2643163 (495 bp)
Type: Others
Protein ID: WP_033710858.1
Location: 2643244..2643633 (390 bp)
Type: Antitoxin
Protein ID: WP_033710872.1
Location: 2643664..2644242 (579 bp)
Type: Toxin
Protein ID: WP_003876749.1
Location: 2645425..2645985 (561 bp)
Type: Others
Protein ID: WP_155267635.1
Location: 2645985..2646785 (801 bp)
Type: Others
Protein ID: WP_033710856.1
Location: 2647318..2648250 (933 bp)
Type: Others
Protein ID: WP_033710855.1
Location: 2638379..2639059 (681 bp)
Type: Others
Protein ID: WP_179944035.1
Location: 2644247..2645314 (1068 bp)
Type: Others
Protein ID: WP_050593662.1
Location: 2646799..2647149 (351 bp)
Type: Others
Protein ID: WP_003878038.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JPH1_RS124502638379..2639059-681WP_179944035.1hypothetical protein-
JPH1_RS124552639139..2640656+1518WP_011724808.1carboxylesterase/lipase family protein-
JPH1_RS124602640675..2642672+1998WP_033710859.1phosphotransferase-
JPH1_RS124652642669..2643163+495WP_033710858.1gluconokinase-
JPH1_RS124702643244..2643633+390WP_033710872.1hypothetical proteinAntitoxin
JPH1_RS124752643664..2644242+579WP_003876749.1zeta toxin family proteinToxin
JPH1_RS124802644247..2645314-1068WP_050593662.1DoxX family membrane protein-
JPH1_RS124852645425..2645985+561WP_155267635.1pyrazinamidase PncA-
JPH1_RS124902645985..2646785+801WP_033710856.1nuclear transport factor 2 family protein-
JPH1_RS124952646799..2647149-351WP_003878038.1DoxX family protein-
JPH1_RS125002647318..2648250+933WP_033710855.1sigma-70 family RNA polymerase sigma factor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T33365 WP_003876749.1 NZ_AP020326:2643664-2644242 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T33365 NZ_AP020326:2643664-2644242 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATAGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13612.07 Da        Isoelectric Point: 5.6717

>AT33365 WP_033710872.1 NZ_AP020326:2643244-2643633 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTLEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT33365 NZ_AP020326:2643244-2643633 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCCTCGAAGAGGGCGTAGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E2W6B4

Antitoxin

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Source
ID
Structure
AlphaFold DBX7VRE0

References