Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1236792..1237445 Replicon chromosome
Accession NZ_AP020326
Organism Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag JPH1_RS06185 Protein ID WP_003872880.1
Coordinates 1236984..1237445 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag JPH1_RS06180 Protein ID WP_003872881.1
Coordinates 1236792..1236980 (+) Length 63 a.a.

Genomic Context

JPH1_RS06170JPH1_RS06175JPH1_RS06180JPH1_RS06185JPH1_RS06190JPH1_RS06195JPH1_RS06200JPH1_RS06210
Location: 1232774..1234360 (1587 bp)
Type: Others
Protein ID: WP_023900196.1
Location: 1234357..1236729 (2373 bp)
Type: Others
Protein ID: WP_088295086.1
Location: 1236792..1236980 (189 bp)
Type: Antitoxin
Protein ID: WP_003872881.1
Location: 1236984..1237445 (462 bp)
Type: Toxin
Protein ID: WP_003872880.1
Location: 1237515..1237949 (435 bp)
Type: Others
Protein ID: WP_023880080.1
Location: 1238948..1240531 (1584 bp)
Type: Others
Protein ID: WP_003872878.1
Location: 1240578..1240959 (382 bp)
Type: Others
Protein ID: Protein_1212
Location: 1241751..1242089 (339 bp)
Type: Others
Protein ID: WP_009975166.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JPH1_RS061701232774..1234360+1587WP_023900196.1serine hydrolase-
JPH1_RS061751234357..1236729+2373WP_088295086.1cation-translocating P-type ATPase-
JPH1_RS061801236792..1236980+189WP_003872881.1antitoxinAntitoxin
JPH1_RS061851236984..1237445+462WP_003872880.1SRPBCC family proteinToxin
JPH1_RS061901237515..1237949+435WP_023880080.1hypothetical protein-
JPH1_RS061951238948..1240531+1584WP_003872878.1DUF4185 domain-containing protein-
JPH1_RS062001240578..1240959+382Protein_1212hypothetical protein-
JPH1_RS062101241751..1242089+339WP_009975166.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T33363 WP_003872880.1 NZ_AP020326:1236984-1237445 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

>T33363 NZ_AP020326:1236984-1237445 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGCTCGGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCAATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT33363 WP_003872881.1 NZ_AP020326:1236792-1236980 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp

>AT33363 NZ_AP020326:1236792-1236980 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E2WC18

References