Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1049929..1050612 Replicon chromosome
Accession NZ_AP020326
Organism Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag JPH1_RS05190 Protein ID WP_007168487.1
Coordinates 1049929..1050336 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag JPH1_RS05195 Protein ID WP_033711258.1
Coordinates 1050340..1050612 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JPH1_RS05160 1045197..1046591 + 1395 WP_198001556.1 group II intron reverse transcriptase/maturase -
JPH1_RS05165 1046707..1047165 + 459 Protein_1009 IS30 family transposase -
JPH1_RS05170 1047282..1047452 - 171 Protein_1010 carnitinyl-CoA dehydratase -
JPH1_RS05180 1049201..1049506 - 306 WP_007168485.1 hypothetical protein -
JPH1_RS05185 1049567..1049908 - 342 WP_007168486.1 hypothetical protein -
JPH1_RS05190 1049929..1050336 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
JPH1_RS05195 1050340..1050612 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JPH1_RS05200 1051102..1051323 - 222 Protein_1015 transposase -
JPH1_RS05205 1051367..1053309 - 1943 Protein_1016 tyrosine-type recombinase/integrase -
JPH1_RS05210 1053306..1054355 - 1050 WP_007172498.1 tyrosine-type recombinase/integrase -
JPH1_RS05215 1054424..1055485 - 1062 WP_007172499.1 IS256-like element IS1511 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1023889..1060173 36284
- flank IS/Tn - - 1054424..1055485 1061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T33362 WP_007168487.1 NZ_AP020326:c1050336-1049929 [Mycobacterium avium subsp. hominissuis]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T33362 NZ_AP020326:c1050336-1049929 [Mycobacterium avium subsp. hominissuis]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT33362 WP_033711258.1 NZ_AP020326:c1050612-1050340 [Mycobacterium avium subsp. hominissuis]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT33362 NZ_AP020326:c1050612-1050340 [Mycobacterium avium subsp. hominissuis]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References