Detailed information of TA system TA033360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 718790..719295
• Replicon: chromosome
• Accession: NZ_AP020326
• Organism: Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: X7VD93
• Locus tag: JPH1_RS03635
• Protein ID: WP_007172144.1
• Coordinates: 718790..719095 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: -
• Locus tag: JPH1_RS03640
• Protein ID: WP_151834792.1
• Coordinates: 719092..719295 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JPH1_RS27220	713868..714008	+	141	WP_007172137.1	hypothetical protein	-
JPH1_RS03610	714005..714391	+	387	WP_007172138.1	YbaB/EbfC family nucleoid-associated protein	-
JPH1_RS03615	714461..715138	+	678	WP_101930854.1	hypothetical protein	-
JPH1_RS03620	715138..715470	+	333	WP_033717256.1	hypothetical protein	-
JPH1_RS03625	715758..716045	+	288	WP_007172141.1	hypothetical protein	-
JPH1_RS27225	716064..718418	+	2355	WP_007172142.1	hypothetical protein	-
JPH1_RS03635	718790..719095	-	306	WP_007172144.1	hypothetical protein	Toxin
JPH1_RS03640	719092..719295	-	204	WP_151834792.1	antitoxin	Antitoxin
JPH1_RS03650	719805..721295	+	1491	WP_007172147.1	type VII secretion protein EccB	-
JPH1_RS03655	721369..722424	+	1056	WP_007172148.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (3-33)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 10428.23 Da
• Isoelectric Point: 3.9382

>T33360 WP_007172144.1 NZ_AP020326:c719095-718790 [Mycobacterium avium subsp. hominissuis]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Nucleotide

• Length: 306 bp

>T33360 NZ_AP020326:c719095-718790 [Mycobacterium avium subsp. hominissuis]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7338.17 Da
• Isoelectric Point: 4.4760

>AT33360 WP_151834792.1 NZ_AP020326:c719295-719092 [Mycobacterium avium subsp. hominissuis]
MIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKVYQANRAAGL

Nucleotide

• Length: 204 bp

>AT33360 NZ_AP020326:c719295-719092 [Mycobacterium avium subsp. hominissuis]
ATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCTGAATCGTTCAGAGATGATCGAACG
AGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTGTGCCAACGCTCGACATCGACGCCT
ACGCGGAGAAGGTCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Structures

Toxin

• AlphaFold DB: A0A1X1XDZ0