Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1255886..1256363 Replicon chromosome
Accession NZ_AP020324
Organism Staphylococcus aureus strain KUN1163

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KUH140013_RS06570 Protein ID WP_000052076.1
Coordinates 1256175..1256363 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KUH140013_RS06565 Protein ID WP_001059690.1
Coordinates 1255886..1256146 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUH140013_RS06530 1251278..1251994 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KUH140013_RS06535 1252142..1252564 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KUH140013_RS06540 1252963..1253457 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KUH140013_RS06545 1253612..1254228 + 617 Protein_1236 amino acid transporter -
KUH140013_RS06550 1254301..1254882 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
KUH140013_RS06555 1255109..1255345 + 237 WP_000349581.1 hypothetical protein -
KUH140013_RS06560 1255342..1255545 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KUH140013_RS06565 1255886..1256146 + 261 WP_001059690.1 hypothetical protein Antitoxin
KUH140013_RS06570 1256175..1256363 + 189 WP_000052076.1 hypothetical protein Toxin
KUH140013_RS06575 1256551..1257120 + 570 WP_001106654.1 hypothetical protein -
KUH140013_RS06580 1257208..1257492 + 285 WP_001004399.1 hypothetical protein -
KUH140013_RS06585 1257554..1257772 + 219 WP_000005886.1 hypothetical protein -
KUH140013_RS06590 1258264..1258464 - 201 WP_001059082.1 cold-shock protein -
KUH140013_RS06595 1258821..1259507 - 687 WP_000141557.1 thermonuclease family protein -
KUH140013_RS06600 1259848..1260369 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / seb 1252963..1284221 31258


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-91)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T33349 WP_000052076.1 NZ_AP020324:1256175-1256363 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33349 NZ_AP020324:1256175-1256363 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33349 WP_001059690.1 NZ_AP020324:1255886-1256146 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33349 NZ_AP020324:1255886-1256146 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References