Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2390955..2391478 Replicon chromosome
Accession NZ_AP020322
Organism Staphylococcus aureus strain KUH180129

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag F6Y14_RS12105 Protein ID WP_000074049.1
Coordinates 2391212..2391478 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag F6Y14_RS12100 Protein ID WP_000587616.1
Coordinates 2390955..2391212 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y14_RS12080 2387452..2388201 - 750 WP_000072461.1 CPBP family intramembrane metalloprotease -
F6Y14_RS12085 2388396..2389973 + 1578 WP_150073943.1 FMN-binding glutamate synthase family protein -
F6Y14_RS12090 2390141..2390596 - 456 WP_000732076.1 DUF1307 domain-containing protein -
F6Y14_RS12100 2390955..2391212 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6Y14_RS12105 2391212..2391478 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
F6Y14_RS12110 2391833..2392909 + 1077 WP_001076673.1 M42 family metallopeptidase -
F6Y14_RS12115 2393157..2393820 + 664 Protein_2290 ATP-binding cassette domain-containing protein -
F6Y14_RS12120 2393813..2394589 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
F6Y14_RS12125 2394985..2396172 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T33328 WP_000074049.1 NZ_AP020322:2391212-2391478 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T33328 NZ_AP020322:2391212-2391478 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT33328 WP_000587616.1 NZ_AP020322:2390955-2391212 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT33328 NZ_AP020322:2390955-2391212 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References