Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1263613..1264090 Replicon chromosome
Accession NZ_AP020322
Organism Staphylococcus aureus strain KUH180129

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag F6Y14_RS06635 Protein ID WP_000052076.1
Coordinates 1263902..1264090 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F6Y14_RS06630 Protein ID WP_001059690.1
Coordinates 1263613..1263873 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y14_RS06595 1259006..1259722 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
F6Y14_RS06600 1259870..1260292 + 423 Protein_1240 organic hydroperoxide resistance protein -
F6Y14_RS06605 1260691..1261185 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F6Y14_RS06610 1261340..1261957 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
F6Y14_RS06615 1262030..1262611 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
F6Y14_RS06620 1262836..1263072 + 237 WP_000349581.1 hypothetical protein -
F6Y14_RS06625 1263069..1263272 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F6Y14_RS06630 1263613..1263873 + 261 WP_001059690.1 hypothetical protein Antitoxin
F6Y14_RS06635 1263902..1264090 + 189 WP_000052076.1 hypothetical protein Toxin
F6Y14_RS06640 1264278..1264847 + 570 WP_001106654.1 hypothetical protein -
F6Y14_RS06645 1264935..1265219 + 285 WP_001004399.1 hypothetical protein -
F6Y14_RS06650 1265281..1265499 + 219 WP_000005886.1 hypothetical protein -
F6Y14_RS06655 1265991..1266191 - 201 WP_001059082.1 cold-shock protein -
F6Y14_RS06660 1266548..1267234 - 687 WP_000141557.1 thermonuclease family protein -
F6Y14_RS06665 1267575..1268096 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T33327 WP_000052076.1 NZ_AP020322:1263902-1264090 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33327 NZ_AP020322:1263902-1264090 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33327 WP_001059690.1 NZ_AP020322:1263613-1263873 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33327 NZ_AP020322:1263613-1263873 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References