Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 510621..511409 Replicon chromosome
Accession NZ_AP020322
Organism Staphylococcus aureus strain KUH180129

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag F6Y14_RS02805 Protein ID WP_000525004.1
Coordinates 510621..511082 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag F6Y14_RS02810 Protein ID WP_000333630.1
Coordinates 511095..511409 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y14_RS02780 505631..507658 + 2028 WP_001558502.1 hypothetical protein -
F6Y14_RS02785 507701..508906 - 1206 WP_000264751.1 site-specific integrase -
F6Y14_RS02790 509032..509646 + 615 WP_000191464.1 hypothetical protein -
F6Y14_RS02795 509643..509789 - 147 WP_001795334.1 hypothetical protein -
F6Y14_RS02800 510067..510603 - 537 WP_150073891.1 hypothetical protein -
F6Y14_RS02805 510621..511082 - 462 WP_000525004.1 hypothetical protein Toxin
F6Y14_RS02810 511095..511409 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
F6Y14_RS02815 511561..511797 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
F6Y14_RS02820 511811..512587 + 777 WP_001148544.1 Rha family transcriptional regulator -
F6Y14_RS02825 512616..512759 + 144 WP_000939498.1 hypothetical protein -
F6Y14_RS02830 512749..512958 - 210 WP_000642492.1 hypothetical protein -
F6Y14_RS02835 513014..513259 + 246 WP_001025401.1 DUF2829 domain-containing protein -
F6Y14_RS02840 513228..513593 - 366 WP_001128433.1 hypothetical protein -
F6Y14_RS02845 513648..513863 + 216 WP_001097552.1 hypothetical protein -
F6Y14_RS02850 513888..514151 + 264 WP_001124198.1 helix-turn-helix domain-containing protein -
F6Y14_RS02855 514163..514324 + 162 WP_001285948.1 DUF1270 domain-containing protein -
F6Y14_RS02860 514402..514725 + 324 WP_000174998.1 hypothetical protein -
F6Y14_RS02865 514740..515102 + 363 WP_000985977.1 hypothetical protein -
F6Y14_RS02870 515099..516265 + 1167 WP_061740011.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 504712..554177 49465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T33323 WP_000525004.1 NZ_AP020322:c511082-510621 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T33323 NZ_AP020322:c511082-510621 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT33323 WP_000333630.1 NZ_AP020322:c511409-511095 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT33323 NZ_AP020322:c511409-511095 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References