33316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2901081..2901610 Replicon chromosome
Accession NZ_AP020320
Organism Staphylococcus aureus strain KUH180062

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag F6Y17_RS14730 Protein ID WP_001103933.1
Coordinates 2901293..2901610 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag F6Y17_RS14725 Protein ID WP_001058487.1
Coordinates 2901081..2901290 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y17_RS14690 2896312..2896596 + 285 WP_000917289.1 co-chaperone GroES -
F6Y17_RS14695 2896672..2898288 + 1617 WP_000240642.1 chaperonin GroEL -
F6Y17_RS14700 2898357..2899529 - 1173 WP_000179353.1 site-specific integrase -
F6Y17_RS14705 2899543..2900265 - 723 WP_000672427.1 helix-turn-helix domain-containing protein -
F6Y17_RS14710 2900418..2900624 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
F6Y17_RS14715 2900628..2900945 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
F6Y17_RS14720 2900942..2901088 + 147 WP_000708434.1 hypothetical protein -
F6Y17_RS14725 2901081..2901290 + 210 WP_001058487.1 hypothetical protein Antitoxin
F6Y17_RS14730 2901293..2901610 + 318 WP_001103933.1 DUF1474 family protein Toxin
F6Y17_RS14735 2901677..2902546 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
F6Y17_RS14740 2902563..2904032 + 1470 WP_001838755.1 virulence-associated E family protein -
F6Y17_RS14750 2904318..2904680 + 363 WP_001039169.1 hypothetical protein -
F6Y17_RS14755 2904682..2904966 + 285 WP_000998179.1 hypothetical protein -
F6Y17_RS14760 2904963..2905604 + 642 WP_001019811.1 hypothetical protein -
F6Y17_RS14765 2906140..2906481 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2893299..2938994 45695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T33316 WP_001103933.1 NZ_AP020320:2901293-2901610 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T33316 NZ_AP020320:2901293-2901610 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT33316 WP_001058487.1 NZ_AP020320:2901081-2901290 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT33316 NZ_AP020320:2901081-2901290 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References