33305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1256733..1257210 Replicon chromosome
Accession NZ_AP020320
Organism Staphylococcus aureus strain KUH180062

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag F6Y17_RS06570 Protein ID WP_000052076.1
Coordinates 1257022..1257210 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F6Y17_RS06565 Protein ID WP_001059690.1
Coordinates 1256733..1256993 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y17_RS06530 1252125..1252841 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
F6Y17_RS06535 1252989..1253411 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
F6Y17_RS06540 1253810..1254304 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F6Y17_RS06545 1254459..1255075 + 617 Protein_1240 amino acid transporter -
F6Y17_RS06550 1255148..1255729 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
F6Y17_RS06555 1255956..1256192 + 237 WP_000349581.1 hypothetical protein -
F6Y17_RS06560 1256189..1256392 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F6Y17_RS06565 1256733..1256993 + 261 WP_001059690.1 hypothetical protein Antitoxin
F6Y17_RS06570 1257022..1257210 + 189 WP_000052076.1 hypothetical protein Toxin
F6Y17_RS06575 1257398..1257967 + 570 WP_001106654.1 hypothetical protein -
F6Y17_RS06580 1258055..1258339 + 285 WP_001004399.1 hypothetical protein -
F6Y17_RS06585 1258401..1258619 + 219 WP_000005886.1 hypothetical protein -
F6Y17_RS06590 1259111..1259311 - 201 WP_001059082.1 cold-shock protein -
F6Y17_RS06595 1259668..1260354 - 687 WP_000141557.1 thermonuclease family protein -
F6Y17_RS06600 1260695..1261216 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / seb 1253810..1285212 31402


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T33305 WP_000052076.1 NZ_AP020320:1257022-1257210 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33305 NZ_AP020320:1257022-1257210 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33305 WP_001059690.1 NZ_AP020320:1256733-1256993 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33305 NZ_AP020320:1256733-1256993 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References