Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2724305..2724819 Replicon chromosome
Accession NZ_AP020318
Organism Staphylococcus aureus strain KUH180038

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag F6Y16_RS13790 Protein ID WP_000581792.1
Coordinates 2724610..2724819 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag F6Y16_RS13785 Protein ID WP_000138932.1
Coordinates 2724305..2724598 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y16_RS13750 2719568..2720209 + 642 WP_000483153.1 thiamine phosphate synthase -
F6Y16_RS13755 2720295..2721167 + 873 WP_000725802.1 membrane protein insertase YidC -
F6Y16_RS13775 2721980..2722627 - 648 WP_001187629.1 HD domain-containing protein -
F6Y16_RS13780 2722655..2724139 - 1485 WP_000571549.1 cardiolipin synthase -
F6Y16_RS13785 2724305..2724598 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
F6Y16_RS13790 2724610..2724819 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
F6Y16_RS13795 2724947..2725084 + 138 WP_000828354.1 hypothetical protein -
F6Y16_RS13800 2725348..2726550 - 1203 WP_001109939.1 rod shape-determining protein RodA -
F6Y16_RS13805 2726868..2727938 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
F6Y16_RS13810 2727953..2729311 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T33293 WP_000581792.1 NZ_AP020318:2724610-2724819 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T33293 NZ_AP020318:2724610-2724819 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT33293 WP_000138932.1 NZ_AP020318:2724305-2724598 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT33293 NZ_AP020318:2724305-2724598 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References