Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1668199..1668728 Replicon chromosome
Accession NZ_AP020318
Organism Staphylococcus aureus strain KUH180038

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag F6Y16_RS08545 Protein ID WP_001103936.1
Coordinates 1668199..1668516 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag F6Y16_RS08550 Protein ID WP_001058486.1
Coordinates 1668519..1668728 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y16_RS08510 1663520..1663861 - 342 WP_001161659.1 hypothetical protein -
F6Y16_RS08515 1664208..1664849 - 642 WP_001019769.1 hypothetical protein -
F6Y16_RS08520 1664846..1665130 - 285 WP_000998182.1 hypothetical protein -
F6Y16_RS08525 1665132..1665494 - 363 WP_108932420.1 pathogenicity island protein -
F6Y16_RS08535 1665780..1667249 - 1470 WP_001795628.1 virulence-associated E family protein -
F6Y16_RS08540 1667266..1668135 - 870 WP_001002700.1 primase alpha helix C-terminal domain-containing protein -
F6Y16_RS08545 1668199..1668516 - 318 WP_001103936.1 DUF1474 family protein Toxin
F6Y16_RS08550 1668519..1668728 - 210 WP_001058486.1 hypothetical protein Antitoxin
F6Y16_RS08555 1668721..1668867 - 147 WP_031824147.1 hypothetical protein -
F6Y16_RS08560 1668879..1669151 - 273 WP_000091734.1 helix-turn-helix domain-containing protein -
F6Y16_RS08565 1669152..1669364 - 213 WP_000794656.1 helix-turn-helix transcriptional regulator -
F6Y16_RS08570 1669508..1670203 + 696 WP_000668212.1 helix-turn-helix domain-containing protein -
F6Y16_RS08575 1670659..1671876 + 1218 WP_000270130.1 site-specific integrase -
F6Y16_RS08580 1672359..1673189 + 831 WP_000357934.1 KilA-N domain-containing protein -
F6Y16_RS08585 1673371..1673613 - 243 WP_000897044.1 30S ribosomal protein S18 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1652517..1678231 25714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12554.16 Da        Isoelectric Point: 4.7281

>T33284 WP_001103936.1 NZ_AP020318:c1668516-1668199 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKKELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAQKLKITE

Download         Length: 318 bp

>T33284 NZ_AP020318:c1668516-1668199 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAAAGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT33284 WP_001058486.1 NZ_AP020318:c1668728-1668519 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT33284 NZ_AP020318:c1668728-1668519 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References