Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1201867..1202344 Replicon chromosome
Accession NZ_AP020318
Organism Staphylococcus aureus strain KUH180038

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag F6Y16_RS06145 Protein ID WP_000052078.1
Coordinates 1202156..1202344 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F6Y16_RS06140 Protein ID WP_001059690.1
Coordinates 1201867..1202127 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y16_RS06105 1197260..1197976 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
F6Y16_RS06110 1198124..1198546 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
F6Y16_RS06115 1198945..1199439 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F6Y16_RS06120 1199594..1200211 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
F6Y16_RS06125 1200284..1200865 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
F6Y16_RS06130 1201090..1201326 + 237 WP_000368687.1 hypothetical protein -
F6Y16_RS06135 1201323..1201526 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F6Y16_RS06140 1201867..1202127 + 261 WP_001059690.1 hypothetical protein Antitoxin
F6Y16_RS06145 1202156..1202344 + 189 WP_000052078.1 hypothetical protein Toxin
F6Y16_RS06150 1202532..1203101 + 570 WP_001106654.1 hypothetical protein -
F6Y16_RS06155 1203189..1203473 + 285 WP_001004395.1 hypothetical protein -
F6Y16_RS06160 1203535..1203753 + 219 WP_000005886.1 hypothetical protein -
F6Y16_RS06165 1204250..1204450 - 201 WP_001059082.1 cold-shock protein -
F6Y16_RS06170 1204807..1205493 - 687 WP_001548082.1 thermonuclease family protein -
F6Y16_RS06175 1205834..1206304 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T33283 WP_000052078.1 NZ_AP020318:1202156-1202344 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33283 NZ_AP020318:1202156-1202344 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33283 WP_001059690.1 NZ_AP020318:1201867-1202127 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33283 NZ_AP020318:1201867-1202127 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References