33265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1152802..1153279 Replicon chromosome
Accession NZ_AP020316
Organism Staphylococcus aureus strain KUH140331

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag F6Y18_RS05870 Protein ID WP_000052076.1
Coordinates 1153091..1153279 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F6Y18_RS05865 Protein ID WP_001059690.1
Coordinates 1152802..1153062 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y18_RS05830 1148195..1148911 - 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -
F6Y18_RS05835 1149059..1149481 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
F6Y18_RS05840 1149880..1150374 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F6Y18_RS05845 1150529..1151146 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
F6Y18_RS05850 1151219..1151800 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
F6Y18_RS05855 1152025..1152261 + 237 WP_000377079.1 hypothetical protein -
F6Y18_RS05860 1152258..1152461 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F6Y18_RS05865 1152802..1153062 + 261 WP_001059690.1 hypothetical protein Antitoxin
F6Y18_RS05870 1153091..1153279 + 189 WP_000052076.1 hypothetical protein Toxin
F6Y18_RS05875 1153467..1154036 + 570 WP_001106652.1 hypothetical protein -
F6Y18_RS05880 1154124..1154408 + 285 WP_001004394.1 hypothetical protein -
F6Y18_RS05885 1154470..1154695 + 226 Protein_1105 hypothetical protein -
F6Y18_RS05890 1155190..1155390 - 201 WP_001059082.1 cold-shock protein -
F6Y18_RS05895 1155747..1156433 - 687 WP_001566557.1 thermonuclease family protein -
F6Y18_RS05900 1156774..1157244 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T33265 WP_000052076.1 NZ_AP020316:1153091-1153279 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33265 NZ_AP020316:1153091-1153279 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33265 WP_001059690.1 NZ_AP020316:1152802-1153062 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33265 NZ_AP020316:1152802-1153062 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References