Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1669789..1670318 Replicon chromosome
Accession NZ_AP020313
Organism Staphylococcus aureus strain KUH140046

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag F6Y15_RS08555 Protein ID WP_001103936.1
Coordinates 1669789..1670106 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag F6Y15_RS08560 Protein ID WP_001058486.1
Coordinates 1670109..1670318 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y15_RS08520 1665110..1665451 - 342 WP_001161659.1 hypothetical protein -
F6Y15_RS08525 1665798..1666439 - 642 WP_001019769.1 hypothetical protein -
F6Y15_RS08530 1666436..1666720 - 285 WP_000998182.1 hypothetical protein -
F6Y15_RS08535 1666722..1667084 - 363 WP_108932420.1 pathogenicity island protein -
F6Y15_RS08545 1667370..1668839 - 1470 WP_150060324.1 virulence-associated E family protein -
F6Y15_RS08550 1668856..1669725 - 870 Protein_1599 primase alpha helix C-terminal domain-containing protein -
F6Y15_RS08555 1669789..1670106 - 318 WP_001103936.1 DUF1474 family protein Toxin
F6Y15_RS08560 1670109..1670318 - 210 WP_001058486.1 hypothetical protein Antitoxin
F6Y15_RS08565 1670311..1670457 - 147 WP_031824147.1 hypothetical protein -
F6Y15_RS08570 1670469..1670741 - 273 WP_000091734.1 helix-turn-helix domain-containing protein -
F6Y15_RS08575 1670742..1670954 - 213 WP_000794656.1 helix-turn-helix transcriptional regulator -
F6Y15_RS08580 1671098..1671793 + 696 WP_000668212.1 helix-turn-helix domain-containing protein -
F6Y15_RS08585 1672249..1673466 + 1218 WP_000270130.1 site-specific integrase -
F6Y15_RS08590 1673949..1674779 + 831 WP_000357934.1 KilA-N domain-containing protein -
F6Y15_RS08595 1674961..1675203 - 243 WP_000897044.1 30S ribosomal protein S18 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1654107..1679821 25714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12554.16 Da        Isoelectric Point: 4.7281

>T33248 WP_001103936.1 NZ_AP020313:c1670106-1669789 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKKELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAQKLKITE

Download         Length: 318 bp

>T33248 NZ_AP020313:c1670106-1669789 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAAAGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT33248 WP_001058486.1 NZ_AP020313:c1670318-1670109 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT33248 NZ_AP020313:c1670318-1670109 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References