Detailed information of TA system TA033248

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1669789..1670318
• Replicon: chromosome
• Accession: NZ_AP020313
• Organism: Staphylococcus aureus strain KUH140046

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: F6Y15_RS08555
• Protein ID: WP_001103936.1
• Coordinates: 1669789..1670106 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: F6Y15_RS08560
• Protein ID: WP_001058486.1
• Coordinates: 1670109..1670318 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y15_RS08520	1665110..1665451	-	342	WP_001161659.1	hypothetical protein	-
F6Y15_RS08525	1665798..1666439	-	642	WP_001019769.1	hypothetical protein	-
F6Y15_RS08530	1666436..1666720	-	285	WP_000998182.1	hypothetical protein	-
F6Y15_RS08535	1666722..1667084	-	363	WP_108932420.1	pathogenicity island protein	-
F6Y15_RS08545	1667370..1668839	-	1470	WP_150060324.1	virulence-associated E family protein	-
F6Y15_RS08550	1668856..1669725	-	870	Protein_1599	primase alpha helix C-terminal domain-containing protein	-
F6Y15_RS08555	1669789..1670106	-	318	WP_001103936.1	DUF1474 family protein	Toxin
F6Y15_RS08560	1670109..1670318	-	210	WP_001058486.1	hypothetical protein	Antitoxin
F6Y15_RS08565	1670311..1670457	-	147	WP_031824147.1	hypothetical protein	-
F6Y15_RS08570	1670469..1670741	-	273	WP_000091734.1	helix-turn-helix domain-containing protein	-
F6Y15_RS08575	1670742..1670954	-	213	WP_000794656.1	helix-turn-helix transcriptional regulator	-
F6Y15_RS08580	1671098..1671793	+	696	WP_000668212.1	helix-turn-helix domain-containing protein	-
F6Y15_RS08585	1672249..1673466	+	1218	WP_000270130.1	site-specific integrase	-
F6Y15_RS08590	1673949..1674779	+	831	WP_000357934.1	KilA-N domain-containing protein	-
F6Y15_RS08595	1674961..1675203	-	243	WP_000897044.1	30S ribosomal protein S18	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1654107..1679821	25714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12554.16 Da
• Isoelectric Point: 4.7281

>T33248 WP_001103936.1 NZ_AP020313:c1670106-1669789 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKKELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAQKLKITE

Nucleotide

• Length: 318 bp

>T33248 NZ_AP020313:c1670106-1669789 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAAAGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT33248 WP_001058486.1 NZ_AP020313:c1670318-1670109 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT33248 NZ_AP020313:c1670318-1670109 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGTGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA