Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1649167..1649678 Replicon chromosome
Accession NZ_AP020311
Organism Staphylococcus aureus strain KUH140013

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag F6Y13_RS08460 Protein ID WP_031904328.1
Coordinates 1649167..1649466 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag F6Y13_RS08465 Protein ID WP_001060744.1
Coordinates 1649469..1649678 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y13_RS08430 1644325..1644903 - 579 WP_000846292.1 hypothetical protein -
F6Y13_RS08435 1644915..1645256 - 342 WP_001161659.1 hypothetical protein -
F6Y13_RS08440 1645603..1646244 - 642 WP_001019770.1 hypothetical protein -
F6Y13_RS08445 1646246..1646518 - 273 WP_001149387.1 hypothetical protein -
F6Y13_RS08450 1646505..1647308 - 804 WP_000148371.1 bifunctional DNA primase/polymerase -
F6Y13_RS08455 1647479..1649092 - 1614 WP_033854769.1 hypothetical protein -
F6Y13_RS08460 1649167..1649466 - 300 WP_031904328.1 DUF1474 family protein Toxin
F6Y13_RS08465 1649469..1649678 - 210 WP_001060744.1 hypothetical protein Antitoxin
F6Y13_RS08470 1649671..1649817 - 147 WP_000784888.1 hypothetical protein -
F6Y13_RS08475 1649829..1650101 - 273 WP_001663084.1 hypothetical protein -
F6Y13_RS08480 1650134..1650346 - 213 WP_000608987.1 hypothetical protein -
F6Y13_RS08485 1650491..1651186 + 696 WP_000700230.1 helix-turn-helix domain-containing protein -
F6Y13_RS08490 1651312..1651833 + 522 WP_001101554.1 hypothetical protein -
F6Y13_RS08500 1652127..1653344 + 1218 WP_000270122.1 site-specific integrase -
F6Y13_RS08505 1653827..1654657 + 831 Protein_1589 KilA-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1633913..1659699 25786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11680.15 Da        Isoelectric Point: 4.4740

>T33230 WP_031904328.1 NZ_AP020311:c1649466-1649167 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSDVSLATESDDA

Download         Length: 300 bp

>T33230 NZ_AP020311:c1649466-1649167 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8286.37 Da        Isoelectric Point: 4.4976

>AT33230 WP_001060744.1 NZ_AP020311:c1649678-1649469 [Staphylococcus aureus]
MNNKQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT33230 NZ_AP020311:c1649678-1649469 [Staphylococcus aureus]
ATGAATAATAAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References