Detailed information of TA system TA033229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1170864..1171341
• Replicon: chromosome
• Accession: NZ_AP020311
• Organism: Staphylococcus aureus strain KUH140013

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: F6Y13_RS05980
• Protein ID: WP_000052078.1
• Coordinates: 1171153..1171341 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: F6Y13_RS05975
• Protein ID: WP_001059690.1
• Coordinates: 1170864..1171124 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y13_RS05940	1166257..1166973	-	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-
F6Y13_RS05945	1167121..1167543	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
F6Y13_RS05950	1167942..1168436	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
F6Y13_RS05955	1168591..1169208	+	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
F6Y13_RS05960	1169281..1169862	-	582	WP_001140693.1	phosphoglycerate mutase family protein	-
F6Y13_RS05965	1170087..1170323	+	237	WP_000368687.1	hypothetical protein	-
F6Y13_RS05970	1170320..1170523	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
F6Y13_RS05975	1170864..1171124	+	261	WP_001059690.1	hypothetical protein	Antitoxin
F6Y13_RS05980	1171153..1171341	+	189	WP_000052078.1	hypothetical protein	Toxin
F6Y13_RS05985	1171529..1172098	+	570	WP_001106654.1	hypothetical protein	-
F6Y13_RS05990	1172186..1172470	+	285	WP_001004395.1	hypothetical protein	-
F6Y13_RS05995	1172532..1172750	+	219	WP_000005886.1	hypothetical protein	-
F6Y13_RS06000	1173247..1173447	-	201	WP_001059082.1	cold-shock protein	-
F6Y13_RS06005	1173804..1174490	-	687	WP_001548082.1	thermonuclease family protein	-
F6Y13_RS06010	1174831..1175301	-	471	WP_000824472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T33229 WP_000052078.1 NZ_AP020311:1171153-1171341 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T33229 NZ_AP020311:1171153-1171341 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT33229 WP_001059690.1 NZ_AP020311:1170864-1171124 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT33229 NZ_AP020311:1170864-1171124 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56