Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1170864..1171341 Replicon chromosome
Accession NZ_AP020311
Organism Staphylococcus aureus strain KUH140013

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag F6Y13_RS05980 Protein ID WP_000052078.1
Coordinates 1171153..1171341 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag F6Y13_RS05975 Protein ID WP_001059690.1
Coordinates 1170864..1171124 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y13_RS05940 1166257..1166973 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
F6Y13_RS05945 1167121..1167543 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
F6Y13_RS05950 1167942..1168436 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
F6Y13_RS05955 1168591..1169208 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
F6Y13_RS05960 1169281..1169862 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
F6Y13_RS05965 1170087..1170323 + 237 WP_000368687.1 hypothetical protein -
F6Y13_RS05970 1170320..1170523 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
F6Y13_RS05975 1170864..1171124 + 261 WP_001059690.1 hypothetical protein Antitoxin
F6Y13_RS05980 1171153..1171341 + 189 WP_000052078.1 hypothetical protein Toxin
F6Y13_RS05985 1171529..1172098 + 570 WP_001106654.1 hypothetical protein -
F6Y13_RS05990 1172186..1172470 + 285 WP_001004395.1 hypothetical protein -
F6Y13_RS05995 1172532..1172750 + 219 WP_000005886.1 hypothetical protein -
F6Y13_RS06000 1173247..1173447 - 201 WP_001059082.1 cold-shock protein -
F6Y13_RS06005 1173804..1174490 - 687 WP_001548082.1 thermonuclease family protein -
F6Y13_RS06010 1174831..1175301 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T33229 WP_000052078.1 NZ_AP020311:1171153-1171341 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T33229 NZ_AP020311:1171153-1171341 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT33229 WP_001059690.1 NZ_AP020311:1170864-1171124 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT33229 NZ_AP020311:1170864-1171124 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References