Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1418012..1418555 Replicon chromosome
Accession NZ_AP020310
Organism Streptococcus agalactiae strain GCMC97051

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag SAGCMC97051_RS07425 Protein ID WP_002943355.1
Coordinates 1418012..1418281 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag SAGCMC97051_RS07430 Protein ID WP_002326825.1
Coordinates 1418283..1418555 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGCMC97051_RS07380 (SAGCMC97051_13880) 1413112..1413402 - 291 WP_000667951.1 hypothetical protein -
SAGCMC97051_RS07385 (SAGCMC97051_13890) 1413452..1413841 - 390 WP_044475264.1 DUF5945 family protein -
SAGCMC97051_RS07390 (SAGCMC97051_13900) 1413838..1414065 - 228 WP_000110922.1 DUF5965 family protein -
SAGCMC97051_RS07395 (SAGCMC97051_13910) 1414093..1415193 - 1101 WP_237395018.1 toprim domain-containing protein -
SAGCMC97051_RS07400 (SAGCMC97051_13920) 1415233..1415871 - 639 WP_060458061.1 hypothetical protein -
SAGCMC97051_RS07405 1415967..1416257 - 291 WP_024408865.1 DUF5966 family protein -
SAGCMC97051_RS07410 (SAGCMC97051_13930) 1416271..1416570 - 300 WP_024408864.1 DUF5962 family protein -
SAGCMC97051_RS07415 (SAGCMC97051_13940) 1416641..1417600 - 960 Protein_1388 hypothetical protein -
SAGCMC97051_RS07420 1417593..1417914 - 322 Protein_1389 DUF4368 domain-containing protein -
SAGCMC97051_RS07425 (SAGCMC97051_13950) 1418012..1418281 - 270 WP_002943355.1 zeta toxin family protein Toxin
SAGCMC97051_RS07430 (SAGCMC97051_13960) 1418283..1418555 - 273 WP_002326825.1 antitoxin Antitoxin
SAGCMC97051_RS07435 (SAGCMC97051_13970) 1418573..1418788 - 216 WP_001835296.1 peptide-binding protein -
SAGCMC97051_RS07440 (SAGCMC97051_13980) 1418859..1419755 - 897 WP_002326827.1 ParA family protein -
SAGCMC97051_RS07445 1419858..1420118 - 261 Protein_1394 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
SAGCMC97051_RS07450 (SAGCMC97051_13990) 1420288..1421025 - 738 WP_010725416.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
SAGCMC97051_RS07455 (SAGCMC97051_14000) 1421149..1421229 - 81 Protein_1396 23S rRNA methyltransferase attenuation leader peptide -
SAGCMC97051_RS07460 (SAGCMC97051_14010) 1421357..1422379 - 1023 WP_162841140.1 IS30 family transposase -
SAGCMC97051_RS07465 (SAGCMC97051_14020) 1422455..1422694 - 240 WP_150352943.1 peptide-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) hylB / wbtL / lmb / scpB 1332114..1482039 149925
- flank IS/Tn erm(B) - 1420288..1422379 2091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T33220 WP_002943355.1 NZ_AP020310:c1418281-1418012 [Streptococcus agalactiae]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T33220 NZ_AP020310:c1418281-1418012 [Streptococcus agalactiae]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAGAAGCACGTTCGCCAAT
GTCAACAAGAGAAATAACTTTAACAGTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT33220 WP_002326825.1 NZ_AP020310:c1418555-1418283 [Streptococcus agalactiae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT33220 NZ_AP020310:c1418555-1418283 [Streptococcus agalactiae]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References