Detailed information of TA system TA033218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 297548..298160
• Replicon: chromosome
• Accession: NZ_AP020310
• Organism: Streptococcus agalactiae strain GCMC97051

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: SAGCMC97051_RS01850
• Protein ID: WP_000384859.1
• Coordinates: 297548..297883 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: SAGCMC97051_RS01855
• Protein ID: WP_000259017.1
• Coordinates: 297873..298160 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGCMC97051_RS01825 (SAGCMC97051_03040)	292746..293387	+	642	WP_000591145.1	hypothetical protein	-
SAGCMC97051_RS01830 (SAGCMC97051_03050)	293687..294562	+	876	WP_050197292.1	replication initiation protein	-
SAGCMC97051_RS01835 (SAGCMC97051_03060)	294598..295032	+	435	WP_001220479.1	hypothetical protein	-
SAGCMC97051_RS01840 (SAGCMC97051_03070)	295349..296605	+	1257	WP_000122836.1	MobV family relaxase	-
SAGCMC97051_RS01845 (SAGCMC97051_03080)	296773..297243	+	471	WP_000130119.1	hypothetical protein	-
SAGCMC97051_RS01850 (SAGCMC97051_03090)	297548..297883	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SAGCMC97051_RS01855 (SAGCMC97051_03100)	297873..298160	-	288	WP_000259017.1	hypothetical protein	Antitoxin
SAGCMC97051_RS01860 (SAGCMC97051_03110)	298593..299747	-	1155	WP_020916100.1	site-specific integrase	-
SAGCMC97051_RS01865 (SAGCMC97051_03120)	299802..300320	-	519	WP_020916101.1	helix-turn-helix transcriptional regulator	-
SAGCMC97051_RS01870 (SAGCMC97051_03130)	300469..300753	+	285	WP_020916102.1	hypothetical protein	-
SAGCMC97051_RS01875 (SAGCMC97051_03140)	300762..301586	+	825	WP_020916103.1	DnaD domain protein	-
SAGCMC97051_RS01880 (SAGCMC97051_03150)	301601..301891	+	291	WP_020916104.1	DUF5962 family protein	-
SAGCMC97051_RS01885 (SAGCMC97051_03160)	301884..302246	+	363	WP_020916105.1	hypothetical protein	-
SAGCMC97051_RS01890 (SAGCMC97051_03170)	302246..302602	+	357	WP_020916106.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T33218 WP_000384859.1 NZ_AP020310:c297883-297548 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T33218 NZ_AP020310:c297883-297548 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT33218 WP_000259017.1 NZ_AP020310:c298160-297873 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT33218 NZ_AP020310:c298160-297873 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6