Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 124611..125118 Replicon chromosome
Accession NZ_AP019863
Organism Rickettsia heilongjiangensis strain HCN-13

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag GOZ20_RS00730 Protein ID WP_014013837.1
Coordinates 124611..124874 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag GOZ20_RS00735 Protein ID WP_014013838.1
Coordinates 124867..125118 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ20_RS00710 120112..120393 + 282 WP_014013832.1 hypothetical protein -
GOZ20_RS07555 120631..121044 + 414 WP_158306289.1 Sca4 family protein -
GOZ20_RS00715 121148..122542 - 1395 WP_014013834.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
GOZ20_RS00720 122539..123195 - 657 WP_014013835.1 lysophospholipid acyltransferase family protein -
GOZ20_RS00725 123346..124551 - 1206 WP_014013836.1 pyridoxal phosphate-dependent aminotransferase -
GOZ20_RS00730 124611..124874 - 264 WP_014013837.1 Txe/YoeB family addiction module toxin Toxin
GOZ20_RS00735 124867..125118 - 252 WP_014013838.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GOZ20_RS00740 125258..126262 + 1005 WP_014013839.1 methyltransferase domain-containing protein -
GOZ20_RS00745 126267..127022 + 756 WP_014013840.1 VacJ family lipoprotein -
GOZ20_RS00750 127042..127641 + 600 WP_014013841.1 phospholipid-binding protein MlaC -
GOZ20_RS00755 127866..128153 + 288 WP_041404299.1 ribose-phosphate pyrophosphokinase-like domain-containing protein -
GOZ20_RS07980 128340..128729 + 390 WP_197535037.1 palindromic element RPE1 domain-containing protein -
GOZ20_RS00770 128874..129941 + 1068 WP_014013842.1 alanine racemase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T33212 WP_014013837.1 NZ_AP019863:c124874-124611 [Rickettsia heilongjiangensis]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T33212 NZ_AP019863:c124874-124611 [Rickettsia heilongjiangensis]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGTGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCATCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT33212 WP_014013838.1 NZ_AP019863:c125118-124867 [Rickettsia heilongjiangensis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT33212 NZ_AP019863:c125118-124867 [Rickettsia heilongjiangensis]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCTGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3RG12

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3RZ38

References