Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 124616..125123 Replicon chromosome
Accession NZ_AP019862
Organism Rickettsia heilongjiangensis strain CH8-1

Toxin (Protein)


Gene name relB Uniprot ID G4KM08
Locus tag GOZ09_RS00730 Protein ID WP_014013837.1
Coordinates 124616..124879 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag GOZ09_RS00735 Protein ID WP_014013838.1
Coordinates 124872..125123 (-) Length 84 a.a.

Genomic Context

GOZ09_RS00710GOZ09_RS07550GOZ09_RS00740GOZ09_RS00745GOZ09_RS00750GOZ09_RS00755GOZ09_RS07990GOZ09_RS00770GOZ09_RS00715GOZ09_RS00720GOZ09_RS00725GOZ09_RS00730GOZ09_RS00735
Location: 120117..120398 (282 bp)
Type: Others
Protein ID: WP_014013832.1
Location: 120636..121049 (414 bp)
Type: Others
Protein ID: WP_158306289.1
Location: 125263..126267 (1005 bp)
Type: Others
Protein ID: WP_014013839.1
Location: 126272..127027 (756 bp)
Type: Others
Protein ID: WP_014013840.1
Location: 127047..127646 (600 bp)
Type: Others
Protein ID: WP_014013841.1
Location: 127871..128158 (288 bp)
Type: Others
Protein ID: WP_041404299.1
Location: 128345..128734 (390 bp)
Type: Others
Protein ID: WP_197535037.1
Location: 128879..129946 (1068 bp)
Type: Others
Protein ID: WP_014013842.1
Location: 121153..122547 (1395 bp)
Type: Others
Protein ID: WP_014013834.1
Location: 122544..123200 (657 bp)
Type: Others
Protein ID: WP_014013835.1
Location: 123351..124556 (1206 bp)
Type: Others
Protein ID: WP_014013836.1
Location: 124616..124879 (264 bp)
Type: Toxin
Protein ID: WP_014013837.1
Location: 124872..125123 (252 bp)
Type: Antitoxin
Protein ID: WP_014013838.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GOZ09_RS00710120117..120398+282WP_014013832.1hypothetical protein-
GOZ09_RS07550120636..121049+414WP_158306289.1Sca4 family protein-
GOZ09_RS00715121153..122547-1395WP_014013834.1lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase-
GOZ09_RS00720122544..123200-657WP_014013835.1lysophospholipid acyltransferase family protein-
GOZ09_RS00725123351..124556-1206WP_014013836.1pyridoxal phosphate-dependent aminotransferase-
GOZ09_RS00730124616..124879-264WP_014013837.1Txe/YoeB family addiction module toxinToxin
GOZ09_RS00735124872..125123-252WP_014013838.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GOZ09_RS00740125263..126267+1005WP_014013839.1methyltransferase domain-containing protein-
GOZ09_RS00745126272..127027+756WP_014013840.1VacJ family lipoprotein-
GOZ09_RS00750127047..127646+600WP_014013841.1phospholipid-binding protein MlaC-
GOZ09_RS00755127871..128158+288WP_041404299.1ribose-phosphate pyrophosphokinase-like domain-containing protein-
GOZ09_RS07990128345..128734+390WP_197535037.1palindromic element RPE1 domain-containing protein-
GOZ09_RS00770128879..129946+1068WP_014013842.1alanine racemase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10590.39 Da        Isoelectric Point: 9.8255

>T33210 WP_014013837.1 NZ_AP019862:c124879-124616 [Rickettsia heilongjiangensis]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T33210 NZ_AP019862:c124879-124616 [Rickettsia heilongjiangensis]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGTGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCATCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT33210 WP_014013838.1 NZ_AP019862:c125123-124872 [Rickettsia heilongjiangensis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT33210 NZ_AP019862:c125123-124872 [Rickettsia heilongjiangensis]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCTGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F3RG12

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H3RZ38

References